MicL sRNA

MicL sRNA

Predicted secondary structure and sequence conservation of MicL small RNA
Identifiers
Rfam RF02654
Other data
Domain(s) Bacteria
GO 0030371
SO 0000370

MicL RNA (mRNA-interfering complementary RNA regulator of Lpp) is a σ E transcription factor-dependent small non-coding RNA. It was discovered in E. coli. Together with MicA and RybB sRNAs, MicL sRNA down-regulates the synthesis of abundant outer membrane proteins in response to stress. MicL specifically targets mRNA of lipoprotein Lpp, preventing its translation.[1]

References

  1. ↑ Guo, Monica S.; Updegrove, Taylor B.; Gogol, Emily B.; Shabalina, Svetlana A.; Gross, Carol A.; Storz, Gisela (2014-07-15). "MicL, a new σE-dependent sRNA, combats envelope stress by repressing synthesis of Lpp, the major outer membrane lipoprotein". Genes & Development. 28 (14): 1620–1634. ISSN 1549-5477. PMC 4102768 Freely accessible. PMID 25030700. doi:10.1101/gad.243485.114.


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