Mesangial proliferative glomerulonephritis

Mesangial proliferative glomerulonephritis

Renal corpuscle. Intraglomerular mesangium is #5a.
Classification and external resources
Specialty	urology
ICD-10	N00.3-N08.3
DiseasesDB	31877

Mesangial proliferative glomerulonephritis is a form of glomerulonephritis associated primarily with the mesangium.^[1] There is some evidence that interleukin-10 may inhibit it in an animal model.^[2] It is classified as type II lupus nephritis by the World Health Organization (WHO).

Mechanism

Mesangial cells in the renal glomerulus use endocytosis to take up and degrade circulating immunoglobulin. This normal process stimulates mesangial cell proliferation and matrix deposition. Therefore, during times of elevated circulating immunoglobulin (i.e. lupus and IgA nephropathy) one would expect to see an increased number of mesangial cells and matrix in the glomerulus. This is characteristic of nephritic syndromes.

References

↑ "Definition: mesangial proliferative glomerulonephritis from Online Medical Dictionary".
↑ Kitching AR, Katerelos M, Mudge SJ, Tipping PG, Power DA, Holdsworth SR (April 2002). "Interleukin-10 inhibits experimental mesangial proliferative glomerulonephritis". Clin. Exp. Immunol. 128 (1): 36–43. PMC 1906377 . PMID 11982588. doi:10.1046/j.1365-2249.2002.01793.x.

Lupus nephritis
Class I (Minimal mesangial glomerulonephritis) Class II (Mesangial proliferative lupus nephritis) Class III (Focal proliferative nephritis) Class IV (Diffuse proliferative nephritis) Class V (Membranous nephritis) Class VI (Glomerulosclerosis)

Diseases of the urinary system (N00–N39, 580–599)

Kidney disease

Glomerules

Primarily
nephrotic

Non-proliferative	Minimal change Focal segmental Membranous
Proliferative	Mesangial proliferative Endocapillary proliferative Membranoproliferative/mesangiocapillary
By condition	Diabetic Amyloidosis

Primarily
nephritic,
RPG

Type I RPG/Type II hypersensitivity	Goodpasture's syndrome
Type II RPG/Type III hypersensitivity	Post-streptococcal Lupus DPGN IgA/Berger's
Type III RPG/Pauci-immune	Granulomatosis with polyangiitis Microscopic polyangiitis Eosinophilic granulomatosis with polyangiitis

General

Tubules

Interstitium

Interstitial nephritis
- Pyelonephritis
- Balkan endemic nephropathy

General

General syndromes	Nephritis Nephrosis Renal failure Acute renal failure Chronic kidney disease Uremic pericarditis Uremia Diabetes insipidus Nephrogenic Renal papilla Renal papillary necrosis Major calyx/pelvis Hydronephrosis Pyonephrosis Reflux nephropathy
Vascular	Renal artery stenosis Renal ischemia Hypertensive nephropathy Renovascular hypertension Renal cortical necrosis
Other	Analgesic nephropathy Renal osteodystrophy Nephroptosis Abderhalden–Kaufmann–Lignac syndrome

Urinary tract

Ureter	Ureteritis Ureterocele Megaureter
Bladder	Cystitis Interstitial cystitis Hunner's ulcer Trigonitis Hemorrhagic cystitis Neurogenic bladder dysfunction Bladder sphincter dyssynergia Vesicointestinal fistula Vesicoureteral reflux
Urethra	Urethritis Non-gonococcal urethritis Urethral syndrome Urethral stricture/Meatal stenosis Urethral caruncle
Any/all	Obstructive uropathy Urinary tract infection Retroperitoneal fibrosis Urolithiasis Bladder stone Kidney stone Renal colic Malakoplakia Urinary incontinence Stress Urge Overflow

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