Mepyramine

Mepyramine
Clinical data
AHFS/Drugs.com International Drug Names
MedlinePlus a606008
ATC code
Identifiers
Synonyms N-[2-(dimethylamino)ethyl]-N-[(4-methoxyphenyl)methyl]pyridin-2-amine
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.001.912
Chemical and physical data
Formula C17H23N3O
Molar mass 285.38 g/mol
3D model (JSmol)
 NYesY (what is this?)  (verify)

Mepyramine, also known as pyrilamine, is a first generation antihistamine, targeting the H1 receptor.[1] However, it rapidly permeates the brain often causing drowsiness. It also has anticholinergic properties. It is used in over-the-counter combination products to treat the common cold and menstrual symptoms.[2] It is also the active ingredient of the topical antihistamine creams Anthisan and Neoantergan, sold for the treatment of insect bites, stings, and nettle rash.

Synthesis

Pyrilamine synthesis:[3][4][5]

See also

References

  1. ↑ Parsons, Mike E.; Ganellin, C. Robin (January 2006). "Histamine and its receptors". British Journal of Pharmacology. 147 (S1): S127–S135. PMC 1760721 Freely accessible. PMID 16402096. doi:10.1038/sj.bjp.0706440.
  2. ↑ Active Ingredients for Midol Complete
  3. ↑ R.J. Horclois, U.S. Patent 2,502,151 (1950).
  4. ↑ Huttrer, C. P.; Djerassi, C.; Beears, W. L.; Mayer, R. L.; Scholz, C. R. (1946). "Heterocyclic amines with antithistaminic activity". Journal of the American Chemical Society. 68 (10): 1999–2002. PMID 21001124. doi:10.1021/ja01214a037.
  5. ↑ D. Bovet, R. Horclois, F. Walthert, C.R. Soc. Biol., 138, 99 (1944).


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