Megazol

Megazol
Clinical data

ATC code	None
Identifiers
IUPAC name 5-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,3,4-thiadiazol-2-amine
CAS Number	19622-55-0
ChemSpider	27598
Chemical and physical data
Formula	C₆H₆N₆O₂S
Molar mass	226.22 g/mol
3D model (JSmol)	Interactive image
SMILES Cn1c(cnc1c2nnc(s2)N)[N+](=O)[O-]

Megazol (CL 64855) is a nitroimidazole based drug that cures some protozoan infections.

A study of nitroimidazoles found the drug extremely effective against T. cruzi and T. brucei which cause Chagas disease and African sleeping sickness, respectively. The drug is considerably more effective than standard benznidazole therapy (for Chagas) which is considered the gold standard.^[1] This is despite that other nitroimidazoles proved ineffective against these pathogens.

References

↑ Hall, BS; Wilkinson, SR (2012). "Activation of Benznidazole by Trypanosomal Type I Nitroreductases Results in Glyoxal Formation". Antimicrob. Agents Chemother. 56 (1): 115–123. PMC 3256028 . PMID 22037852. doi:10.1128/AAC.05135-11.

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