Mebeverine

Mebeverine
Clinical data
Trade names Colofac, Duspamen, Duspatalin and others
AHFS/Drugs.com International Drug Names
Routes of
administration		 By mouth
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
ECHA InfoCard 100.018.546
Chemical and physical data
Formula C25H35NO5
Molar mass 429.6 g/mol
3D model (JSmol)
Chirality Racemic mixture
  (verify)

Mebeverine is a drug used to alleviate some of the symptoms of irritable bowel syndrome. It works by relaxing the muscles in and around the gut.[1]

Mebeverine (Colofac) 135 mg, U.K.

Medical use

Mebeverine is used to alleviate some of the symptoms of irritable bowel syndrome (IBS) and related conditions these conditions; specifically stomach pain and cramps, persistent diarrhea, and flatulence.[2]

Data from controlled clinical trials have not found a difference from placebo in the alleviating stomach pain in people with IBS.[3][4]

It has not been tested in pregnant women nor in pregnant animals so pregnant women should not take it; it is expressed at low levels in breast milk, while no adverse effects have been reported in infants, breastfeeding women should not take this drug.[1]

Adverse effects

Adverse effects include hypersensitivity reactions and allergic reactions, immune system disorders, skin disorders including hives, edema and widespread rashes.[2]

Additionally, the following adverse effects have been reported: heartburn, indigestion, constipation, loss of appetite, general malaise, dizziness, insomnia, headache, and decreased pulse rate.[1]

It does not have systemic anticholinergic side effects.[2]

Mechanism of action

Mebeverine is an anticholinergic but its mechanism of action is not known; it appears to work directly on smooth muscle within the gastrointestinal tract and may have an anesthetic effect, may affect calcium channels, and may affect muscarinic receptors.[2]

It is metabolized mostly by esterases, and almost completely. The metabolites are excreted in urine.[2]

History

It is a second generation papaverine analog, and was first synthesized around the same time as verapamil.[5]

It was first registered in 1965.[6]

Availability

Mebeverine is a generic drug and is available internationally under many brand names.[7]

References

  1. 1 2 3 "Colofac data sheet" (PDF). New Zealand Medicines and Medical Devices Safety Authority. 14 June 2017. Retrieved 21 July 2017.
  2. 1 2 3 4 5 "Colofac Tablets 135mg - Summary of Product Characteristics (SPC)". UK Electronic Medicines Compendium. 26 August 2016. Retrieved 21 July 2017.
  3. ↑ Annaházi, A; Róka, R; Rosztóczy, A; Wittmann, T (28 May 2014). "Role of antispasmodics in the treatment of irritable bowel syndrome.". World journal of gastroenterology. 20 (20): 6031–43. PMC 4033443 Freely accessible. PMID 24876726. doi:10.3748/wjg.v20.i20.6031.
  4. ↑ Darvish-Damavandi, M; Nikfar, S; Abdollahi, M (7 February 2010). "A systematic review of efficacy and tolerability of mebeverine in irritable bowel syndrome.". World journal of gastroenterology. 16 (5): 547–53. PMC 2816265 Freely accessible. PMID 20128021.
  5. ↑ Sneader, Walter (2005). Drug Discovery: A History. John Wiley & Sons. p. 132. ISBN 9780471899792.
  6. ↑ Mebeverine page at druginfosys Page accessed Feb 1, 2015
  7. ↑ International page at drugs.com for Mebeverine Page accessed Feb 1, 2015


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