mdx mouse

The mdx mouse is a popular model for studying Duchenne muscular dystrophy (DMD).

The mdx mouse has a point mutation in its DMD gene, changing the amino acid coding for a glutamine to a threonine. This causes the muscle cells to produce a small, nonfunctional dystrophin protein.[1] As a result, the mouse has a mild form of DMD where there is increased muscle damage and weakness.

References

  1. ↑ "Animal Models - Parent Project Muscular Dystrophy". www.parentprojectmd.org. Retrieved 2016-05-03.


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