Mary Collins (immunologist)

Mary Katharine Levinge Collins is a British Professor of Immunology. She is Dean of Research at the Okinawa Institute of Science and Technology in Japan. Formerly, Collins taught in the Division of Infection and Immunity at University College London, and was the head of the Division of Advanced Therapies at the National Institute for Biological Standards and Control, and the Director of the Medical Research Council Centre for Medical Molecular Virology. Her research group studies the use of viruses as vectors for introducing new genes into cells, which can be useful for experimental cell biology, for clinical applications such as gene therapy, and as cancer vaccines.^[2][3][4][5]

Education

Collins was born in Reading, England and grew up in Cheltenham Spa, attending Cheltenham Ladies' College as a day girl. She won an entrance scholarship to Clare College, University of Cambridge, where she studied Natural Sciences (Biochemistry). She did her postgraduate research work supervised by Enrique Rozengurt at the Imperial Cancer Research Fund for which she was awarded a PhD by the University of London in 1983.^[6]

Career and research

After her PhD, she moved to a postdoctoral fellowship with Avrion Mitchison at University College London studying the locations of T cell receptor gene clusters, and next worked with Richard C. Mulligan at the Whitehead Institute at the Massachusetts Institute of Technology, where she developed retroviral vectors expressing cytokines and cytokine receptors.^[3]

Collins started her research group in 1987 at the Institute of Cancer Research in London and moved in 1997 to University College London, where she has since held a variety of leadership positions. She served as the head of UCL Immunology & Molecular Pathology from 2000 to 2007, became Director of the Medical Research Council Centre for Medical Molecular Virology in 2005, became Director of the UCL Division of Infection & Immunity in 2008, and served as the Dean of the Faculty of Life Sciences between 2009 and 2014. She stepped down as dean to become the head of the Division of Advanced Therapies at the National Institute for Biological Standards and Control.^[3][7]

Collins was among the prominent UCL women scientists featured in a series of interviews published by the MRC in celebration of International Women's Day in 2011^[8] and was one of two UCL women to participate in a women in science event in collaboration with Central Saint Martins College of Art and Design in 2012. In December 2015, it was announced that Professor Collins would become Dean of Research at the Okinawa Institute of Technology. Forbes Magazine speculated that she would supervise of $110m in Japanese government funding at the Institute.^[9][10]

Collins' research group studies the use of viruses, particularly lentiviruses (the group to which the human immunodeficiency virus belongs), as vectors for delivering novel genes to cells and as platforms for the development of vaccines.^[2] Because lentiviruses like HIV specifically infect immune cells called T-cells, a genetically engineered inactivated version of the virus can be used to deliver immunogenic proteins to T-cells to induce an immune response. This system has been studied successfully in laboratory mice.^[11][12]

Awards and honours

Collins was elected a Fellow of the Academy of Medical Sciences (FMedSci).^[3]

Personal

Collins married Tim Hunt in 1995,^[1] who was awarded the Nobel Prize in Physiology or Medicine in 2001. They have two children.^[13]

References