Malonyl-S-ACP decarboxylase

Malonyl-S-ACP decarboxylase
Identifiers
EC number 4.1.1.87
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Malonyl-S-ACP decarboxylase (EC 4.1.1.87, malonyl-S-acyl-carrier protein decarboxylase, MdcD/MdcE, MdcD,E) is an enzyme with systematic name malonyl-(acyl-carrier-protein) carboxy-lyase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

a malonyl-[acyl-carrier protein] + H+ an acetyl-[acyl-carrier protein] + CO2

This enzyme comprises the beta and gamma subunits of the enzyme EC 4.1.1.88.

References

  1. ↑ Schmid, M.; Berg, M.; Hilbi, H.; Dimroth, P. (1996). "Malonate decarboxylase of Klebsiella pneumoniae catalyses the turnover of acetyl and malonyl thioester residues on a coenzyme-A-like prosthetic group". Eur. J. Biochem. 237: 221–228. PMID 8620876. doi:10.1111/j.1432-1033.1996.0221n.x.
  2. ↑ Koo, J.H.; Kim, Y.S. (1999). "Functional evaluation of the genes involved in malonate decarboxylation by Acinetobacter calcoaceticus". Eur. J. Biochem. 266: 683–690. PMID 10561613. doi:10.1046/j.1432-1327.1999.00924.x.
  3. ↑ Handa, S.; Koo, J.H.; Kim, Y.S.; Floss, H.G. (1999). "Stereochemical course of biotin-independent malonate decarboxylase catalysis". Arch. Biochem. Biophys. 370: 93–96. PMID 10496981. doi:10.1006/abbi.1999.1369.
  4. ↑ Chohnan, S.; Akagi, K.; Takamura, Y. (2003). "Functions of malonate decarboxylase subunits from Pseudomonas putida". Biosci. Biotechnol. Biochem. 67: 214–217. PMID 12619701. doi:10.1271/bbb.67.214.
  5. ↑ Dimroth, P.; Hilbi, H. (1997). "Enzymic and genetic basis for bacterial growth on malonate". Mol. Microbiol. 25: 3–10. PMID 11902724. doi:10.1046/j.1365-2958.1997.4611824.x.
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