MX2

MX2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4WHJ, 4X0R
Identifiers
Aliases	MX2, MXB, MX dynamin like GTPase 2
External IDs	HomoloGene: 74299 GeneCards: MX2
Gene location (Human) Chr. Chromosome 21 (human)[1] Band No data available Start 41,361,943 bp[1] End 41,409,390 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • GTP binding • protein binding • microtubule binding • GTPase activity Cellular component • cytosol • cytoplasm • nuclear pore • nucleus • mitochondrial membrane Biological process • defense response • regulation of nucleocytoplasmic transport • mRNA transport • immune system process • response to virus • regulation of cell cycle • defense response to virus • type I interferon signaling pathway • response to interferon-alpha • protein transport • innate immune response • mitochondrial fission • dynamin family protein polymerization involved in mitochondrial fission • membrane fusion • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4600	n/a
Ensembl	ENSG00000183486	n/a
UniProt	P20592	n/a
RefSeq (mRNA)	NM_002463	n/a
RefSeq (protein)	NP_002454	n/a
Location (UCSC)	Chr 21: 41.36 – 41.41 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

For the aircraft and other subjects see MX2 (disambiguation)

Interferon-induced GTP-binding protein Mx2 is a protein that in humans is encoded by the MX2 gene.^[3][4][5]

The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1.^[5]

References

Further reading