IRF4

IRF4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DLL
Identifiers
Aliases	IRF4, LSIRF, MUM1, NF-EM5, SHEP8, interferon regulatory factor 4
External IDs	MGI: 1096873 HomoloGene: 1842 GeneCards: IRF4
Gene location (Human) Chr. Chromosome 6 (human)[1] Band No data available Start 391,739 bp[1] End 411,447 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band No data available Start 30,749,226 bp[2] End 30,766,976 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor binding • regulatory region DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • protein-lysine N-methyltransferase activity • protein binding Cellular component • nuclear nucleosome • cytosol • membrane • nucleoplasm • nucleus Biological process • positive regulation of interleukin-13 biosynthetic process • regulation of transcription, DNA-templated • interferon-gamma-mediated signaling pathway • regulation of T-helper cell differentiation • myeloid dendritic cell differentiation • transcription, DNA-templated • T-helper 17 cell lineage commitment • positive regulation of interleukin-2 biosynthetic process • positive regulation of transcription, DNA-templated • peptidyl-lysine methylation • negative regulation of toll-like receptor signaling pathway • positive regulation of interleukin-10 biosynthetic process • type I interferon signaling pathway • histone H3 acetylation • histone H4 acetylation • positive regulation of DNA binding • T cell activation • positive regulation of interleukin-4 biosynthetic process • positive regulation of transcription from RNA polymerase II promoter • defense response to protozoan • protein methylation • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3662	16364
Ensembl	ENSG00000137265	ENSMUSG00000021356
UniProt	Q15306	Q64287
RefSeq (mRNA)	NM_001195286 NM_002460	NM_013674 NM_001347508
RefSeq (protein)	NP_001182215 NP_002451	NP_001334437 NP_038702
Location (UCSC)	Chr 6: 0.39 – 0.41 Mb	Chr 13: 30.75 – 30.77 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interferon regulatory factor 4 also known as MUM1 is a protein that in humans is encoded by the IRF4 gene,^[5][6][7] located at 6p25-p23.

The MUM1 symbol is polysemous; although it is an older synonym for IRF4 (HGNC:6119), it is also the current HGNC official symbol for melanoma associated antigen (mutated) 1 (HGNC:29641; located at 19p13.3).

Clinical significance

In melanocytic cells the IRF4 gene may be regulated by MITF.^[8] IRF4 is a transcription factor that has been implicated in acute leukemia.^[9] This gene is strongly associated with pigmentation: sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color.^[10] A variant has been implicated in greying of hair.^[11]

Interactions

IRF4 has been shown to interact with:

• BCL6,^[12]
• NFATC2,^[13]
• SPI1,^[14][15] and
• STAT6.^[12]

See also

• Interferon regulatory factors

References

Further reading

External links

• FactorBook IRF4
• IRF4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.