Mucin 7

For the MUC-7 conference, see Message Understanding Conference.

MUC7

Identifiers

MUC7, MG2, mucin 7, secreted

External IDs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	No data available	Start	70,430,492 bp^[1]
Band	No data available	End	70,482,997 bp^[1]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• protein binding
Cellular component	• Golgi lumen • extracellular region • extracellular exosome • plasma membrane • other organism cell membrane • other organism cytoplasm
Biological process	• O-glycan processing • stimulatory C-type lectin receptor signaling pathway • killing of cells of other organism • antimicrobial humoral immune response mediated by antimicrobial peptide
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


4589


n/a

Ensembl


ENSG00000171195


n/a

UniProt


Q8TAX7


n/a

RefSeq (mRNA)


NM_152291 NM_001145006 NM_001145007


n/a

RefSeq (protein)


NP_001138478 NP_001138479 NP_689504


n/a

Location (UCSC)

Chr 4: 70.43 – 70.48 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Mucin-7 is a protein that in humans is encoded by the MUC7 gene.^[3]^[4]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000171195 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ Bobek LA, Liu J, Sait SN, Shows TB, Bobek YA, Levine MJ (Mar 1997). "Structure and chromosomal localization of the human salivary mucin gene, MUC7". Genomics. 31 (3): 277–82. PMID 8838308. doi:10.1006/geno.1996.0049.
↑ "Entrez Gene: MUC7 mucin 7, secreted".

Zalewska A, Zwierz K, Zółkowski K, Gindzieński A (2002). "Structure and biosynthesis of human salivary mucins.". Acta Biochim. Pol. 47 (4): 1067–79. PMID 11996097.
Bobek LA, Tsai H, Biesbrock AR, Levine MJ (1993). "Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7).". J. Biol. Chem. 268 (27): 20563–9. PMID 7690757.
Troxler RF, Iontcheva I, Oppenheim FG, et al. (1998). "Molecular characterization of a major high molecular weight mucin from human sublingual gland.". Glycobiology. 7 (7): 965–73. PMID 9363439. doi:10.1093/glycob/7.7.965.
Prakobphol A, Thomsson KA, Hansson GC, et al. (1998). "Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand activity.". Biochemistry. 37 (14): 4916–27. PMID 9538010. doi:10.1021/bi972612a.
Kirkbride HJ, Bolscher JG, Nazmi K, et al. (2001). "Genetic polymorphism of MUC7: allele frequencies and association with asthma.". Eur. J. Hum. Genet. 9 (5): 347–54. PMID 11378823. doi:10.1038/sj.ejhg.5200642.
Guo JM, Zhang Y, Cheng L, et al. (2002). "Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12.". FEBS Lett. 524 (1–3): 211–8. PMID 12135769. doi:10.1016/S0014-5793(02)03007-7.
Cheng L, Tachibana K, Zhang Y, et al. (2002). "Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T10". FEBS Lett. 531 (2): 115–21. PMID 12417297. doi:10.1016/S0014-5793(02)03399-9.
Banderas-Tarabay JA, Zacarías-D'Oleire IG, Garduño-Estrada R, et al. (2003). "Electrophoretic analysis of whole saliva and prevalence of dental caries. A study in Mexican dental students". Arch. Med. Res. 33 (5): 499–505. PMID 12459324. doi:10.1016/S0188-4409(02)00395-8.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Wang H, Tachibana K, Zhang Y, et al. (2003). "Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14". Biochem. Biophys. Res. Commun. 300 (3): 738–44. PMID 12507512. doi:10.1016/S0006-291X(02)02908-X.
Soares RV, Siqueira CC, Bruno LS, et al. (2003). "MG2 and lactoferrin form a heterotypic complex in salivary secretions". J. Dent. Res. 82 (6): 471–5. PMID 12766201. doi:10.1177/154405910308200613.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Ge J, Catt DM, Gregory RL (2004). "Streptococcus mutans surface alpha-enolase binds salivary mucin MG2 and human plasminogen". Infect. Immun. 72 (11): 6748–52. PMC 523000 . PMID 15501816. doi:10.1128/IAI.72.11.6748-6752.2004.
Grys TE, Siegel MB, Lathem WW, Welch RA (2005). "The StcE protease contributes to intimate adherence of enterohemorrhagic Escherichia coli O157:H7 to host cells". Infect. Immun. 73 (3): 1295–303. PMC 1064933 . PMID 15731026. doi:10.1128/IAI.73.3.1295-1303.2005.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.
Bruno LS, Li X, Wang L, et al. (2005). "Two-hybrid analysis of human salivary mucin MUC7 interactions". Biochim. Biophys. Acta. 1746 (1): 65–72. PMID 16203048. doi:10.1016/j.bbamcr.2005.08.007.
Li S, Intini G, Bobek LA (2006). "Modulation of MUC7 mucin expression by exogenous factors in airway cells in vitro and in vivo". Am. J. Respir. Cell Mol. Biol. 35 (1): 95–102. PMC 2658701 . PMID 16514118. doi:10.1165/rcmb.2005-0305OC.

Protein, glycoconjugate: glycoproteins and glycopeptides

Mucoproteins

Mucin	CD43 CD164 MUC1 MUC2 MUC3A MUC3B MUC4 MUC5AC MUC5B MUC6 MUC7 MUC8 MUC12 MUC13 MUC15 MUC16 MUC17 MUC19 MUC20
Other	Haptoglobin Intrinsic factor Orosomucoid Peptidoglycan Phytohaemagglutinin Ovomucin

Proteoglycans

CS/DS	Decorin Biglycan Versican
HS/CS	Testican Perlecan
CS	Chondroitin sulfate proteoglycans: Aggrecan Neurocan Brevican CD44 CSPG4 CSPG5 Platelet factor 4 Structural maintenance of chromosomes 3
KS	Fibromodulin Lumican Keratocan
HS	Syndecan 1

Other

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Mucin 7

References

Further reading