MT1X

MT1X

Identifiers

MT1X, MT-1l, MT1, metallothionein 1X

External IDs

HomoloGene: 130542 GeneCards: MT1X

Gene location (Human)

Chr.	Chromosome 16 (human)^[1]

Band	No data available	Start	56,682,424 bp^[1]
Band	No data available	End	56,684,196 bp^[1]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• protein binding • metal ion binding • zinc ion binding
Cellular component	• cytoplasm • perinuclear region of cytoplasm • nucleus
Biological process	• response to metal ion • cellular response to erythropoietin • negative regulation of growth • cellular response to cadmium ion • cellular response to zinc ion
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


4501


n/a


ENSG00000187193


n/a


P80297


n/a

RefSeq (mRNA)


NM_005952


n/a

RefSeq (protein)


NP_005943


n/a

Location (UCSC)

Chr 16: 56.68 – 56.68 Mb

n/a

PubMed search

^[2]

n/a

View/Edit Human

Metallothionein 1X, also known as MT1X, is a protein which in humans is encoded by the gene.^[3]^[4]^[5]

See also

Metallothionein

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000187193 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Entrez Gene: MT1X metallothionein 1X".
↑ West AK, Stallings R, Hildebrand CE, Chiu R, Karin M, Richards RI (November 1990). "Human metallothionein genes: structure of the functional locus at 16q13". Genomics. 8 (3): 513–8. PMID 2286373. doi:10.1016/0888-7543(90)90038-V.
↑ Stennard FA, Holloway AF, Hamilton J, West AK (August 1994). "Characterisation of six additional human metallothionein genes". Biochim. Biophys. Acta. 1218 (3): 357–65. PMID 8049263. doi:10.1016/0167-4781(94)90189-9.

Further reading

West AK, Stallings R, Hildebrand CE, et al. (1991). "Human metallothionein genes: structure of the functional locus at 16q13.". Genomics. 8 (3): 513–8. PMID 2286373. doi:10.1016/0888-7543(90)90038-V.
Stennard FA, Holloway AF, Hamilton J, West AK (1994). "Characterisation of six additional human metallothionein genes.". Biochim. Biophys. Acta. 1218 (3): 357–65. PMID 8049263. doi:10.1016/0167-4781(94)90189-9.
Pauwels M, van Weyenbergh J, Soumillion A, et al. (1994). "Induction by zinc of specific metallothionein isoforms in human monocytes.". Eur. J. Biochem. 220 (1): 105–10. PMID 8119276. doi:10.1111/j.1432-1033.1994.tb18603.x.
Mididoddi S, McGuirt JP, Sens MA, et al. (1996). "Isoform-specific expression of metallothionein mRNA in the developing and adult human kidney.". Toxicol. Lett. 85 (1): 17–27. PMID 8619255. doi:10.1016/0378-4274(96)03632-6.
Holloway AF, Stennard FA, West AK (1997). "Human metallothionein gene MT1L mRNA is present in several human tissues but is unlikely to produce a metallothionein protein.". FEBS Lett. 404 (1): 41–4. PMID 9074634. doi:10.1016/S0014-5793(97)00082-3.
Garrett SH, Somji S, Todd JH, et al. (1999). "Differential expression of human metallothionein isoform I mRNA in human proximal tubule cells exposed to metals.". Environ. Health Perspect. Brogan &#38. 106 (12): 825–32. JSTOR 3434126. PMC 1533231 . PMID 9831543. doi:10.2307/3434126.
Hellemans G, Soumillion A, Proost P, et al. (2000). "Metallothioneins in human kidneys and associated tumors". Nephron. 83 (4): 331–40. PMID 10575295. doi:10.1159/000045425.
Garrett SH, Sens MA, Shukla D, et al. (2000). "Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer". Prostate. 43 (2): 125–35. PMID 10754528. doi:10.1002/(SICI)1097-0045(20000501)43:2<125::AID-PROS7>3.0.CO;2-S.
Vandeghinste N, Proost P, De Ley M (2000). "Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes". Cell. Mol. Biol. (Noisy-le-grand). 46 (2): 419–33. PMID 10774930.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMC 310948 . PMID 11076863. doi:10.1101/gr.143000.
Rahman MT, De Ley M (2001). "Metallothionein isogene transcription in red blood cell precursors from human cord blood". Eur. J. Biochem. 268 (3): 849–56. PMID 11168427. doi:10.1046/j.1432-1327.2001.01947.x.
Garrett SH, Belcastro M, Sens MA, et al. (2001). "Acute exposure to arsenite induces metallothionein isoform-specific gene expression in human proximal tubule cells". J. Toxicol. Environ. Health Part A. 64 (4): 343–55. PMID 11693492. doi:10.1080/152873901316981321.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. PMID 12539042. doi:10.1038/nm822.
Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell Proteomics. 3 (4): 311–26. PMID 14718574. doi:10.1074/mcp.M300127-MCP200.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. PMC 528930 . PMID 15489336. doi:10.1101/gr.2576704.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. PMC 1347501 . PMID 16381901. doi:10.1093/nar/gkj139.

PDB gallery

1mhu: THE THREE-DIMENSIONAL STRUCTURE OF HUMAN [113CD7] METALLOTHIONEIN-2 IN SOLUTION DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

1mrb: THREE-DIMENSIONAL STRUCTURE OF RABBIT LIVER CD7 METALLOTHIONEIN-2A IN AQUEOUS SOLUTION DETERMINED BY NUCLEAR MAGNETIC RESONANCE

1mrt: CONFORMATION OF CD-7 METALLOTHIONEIN-2 FROM RAT LIVER IN AQUEOUS SOLUTION DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

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