STK3

STK3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3WWS, 4HKD, 4L0N, 4LG4, 4LGD, 4OH9, 5BRM
Identifiers
Aliases	STK3, KRS1, MST2, serine/threonine kinase 3
External IDs	MGI: 1928487 HomoloGene: 48420 GeneCards: STK3
Gene location (Human) Chr. Chromosome 8 (human)[1] Band No data available Start 98,401,403 bp[1] End 98,942,827 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band No data available Start 34,875,496 bp[2] End 35,155,806 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • protein dimerization activity • protein serine/threonine kinase activator activity • metal ion binding • kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding • magnesium ion binding • protein kinase activity Cellular component • cytoplasm • cytosol • protein complex • nucleus Biological process • regulation of cell differentiation involved in embryonic placenta development • positive regulation of extrinsic apoptotic signaling pathway via death domain receptors • positive regulation of protein kinase B signaling • intracellular signal transduction • phosphorylation • protein stabilization • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of JNK cascade • hippo signaling • endocardium development • protein phosphorylation • primitive hemopoiesis • central nervous system development • positive regulation of apoptotic process • positive regulation of protein binding • cell differentiation involved in embryonic placenta development • positive regulation of fat cell differentiation • negative regulation of organ growth • neural tube formation • negative regulation of canonical Wnt signaling pathway • signal transduction • negative regulation of cell proliferation • hepatocyte apoptotic process • apoptotic process • positive regulation of protein serine/threonine kinase activity • regulation of mitotic cell cycle • signal transduction by protein phosphorylation • stress-activated protein kinase signaling cascade • regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6788	56274
Ensembl	ENSG00000104375	ENSMUSG00000022329
UniProt	Q13188	Q9JI10
RefSeq (mRNA)	NM_001256312 NM_001256313 NM_006281	NM_019635
RefSeq (protein)	NP_001243241 NP_001243242 NP_006272	NP_062609
Location (UCSC)	Chr 8: 98.4 – 98.94 Mb	Chr 8: 34.88 – 35.16 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase 3 is an enzyme that in humans is encoded by the STK3 gene.^[5][6]

Protein kinase activation is a frequent response of cells to treatment with growth factors, chemicals, heat shock, or apoptosis-inducing agents. This protein kinase activation presumably allows cells to resist unfavorable environmental conditions. The yeast 'sterile 20' (Ste20) kinase acts upstream of the mitogen-activated protein kinase (MAPK) cascade that is activated under a variety of stress conditions. MST2 was first identified as a kinase that resembles budding yeast Ste20 (Creasy and Chernoff, 1996) and later as a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand (MIM 134638) (Taylor et al., 1996; Lee et al., 2001).[supplied by OMIM]^[6]

References

Further reading