MPZL1

Identifiers

MPZL1, MPZL1b, PZR, PZR1b, PZRa, PZRb, myelin protein zero like 1

External IDs

MGI: 1915731 HomoloGene: 2939 GeneCards: MPZL1

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	No data available	Start	167,721,192 bp^[1]
Band	No data available	End	167,791,919 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	No data available	Start	165,592,240 bp^[2]
Band	No data available	End	165,634,538 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• protein binding • structural molecule activity
Cellular component	• integral component of membrane • cell surface • integral component of plasma membrane • membrane • focal adhesion
Biological process	• cell-cell signaling • signal transduction • transmembrane receptor protein tyrosine kinase signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9019


68481

Ensembl


ENSG00000197965


ENSMUSG00000026566

UniProt


O95297


Q3TEW6

RefSeq (mRNA)


NM_024569 NM_001146191 NM_003953


NM_001001880 NM_001083897 NM_001347128

RefSeq (protein)


NP_001139663 NP_003944 NP_078845 NP_003944.1


NP_001001880 NP_001077366 NP_001334057

Location (UCSC)

Chr 1: 167.72 – 167.79 Mb

Chr 1: 165.59 – 165.63 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Myelin protein zero-like protein 1 is a protein that in humans is encoded by the MPZL1 gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000197965 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026566 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Zhao ZJ, Zhao R (Dec 1998). "Purification and cloning of PZR, a binding protein and putative physiological substrate of tyrosine phosphatase SHP-2". J Biol Chem. 273 (45): 29367–72. PMID 9792637. doi:10.1074/jbc.273.45.29367.
↑ "Entrez Gene: MPZL1 myelin protein zero-like 1".

Zhao R, Zhao ZJ (2000). "Dissecting the interaction of SHP-2 with PZR, an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs.". J. Biol. Chem. 275 (8): 5453–9. PMID 10681522. doi:10.1074/jbc.275.8.5453.
Zhao R, Guerrah A, Tang H, Zhao ZJ (2002). "Cell surface glycoprotein PZR is a major mediator of concanavalin A-induced cell signaling.". J. Biol. Chem. 277 (10): 7882–8. PMID 11751924. doi:10.1074/jbc.M111914200.
Tang DS, Yu KP, Tang XX, et al. (2000). "Cloning of Human Myelin Protein Zero-like Genes by Bioinformatics Strategy.". Sheng wu hua xue yu sheng wu wu li xue bao Acta Biochimica et Biophysica Sinica. 32 (4): 364–368. PMID 12075424.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.". Mol. Vis. 8: 205–20. PMID 12107410.
Zannettino AC, Roubelakis M, Welldon KJ, et al. (2003). "Novel mesenchymal and haematopoietic cell isoforms of the SHP-2 docking receptor, PZR: identification, molecular cloning and effects on cell migration.". Biochem. J. 370 (Pt 2): 537–49. PMC 1223174 . PMID 12410637. doi:10.1042/BJ20020935.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Zhao R, Zhao ZJ (2003). "Identification of a variant form of PZR lacking immunoreceptor tyrosine-based inhibitory motifs.". Biochem. Biophys. Res. Commun. 303 (4): 1028–33. PMID 12684038. doi:10.1016/S0006-291X(03)00484-4.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. PMC 403697 . PMID 12975309. doi:10.1101/gr.1293003.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. PMC 442147 . PMID 15231747. doi:10.1101/gr.2122004.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Blanchetot C, Chagnon M, Dubé N, et al. (2005). "Substrate-trapping techniques in the identification of cellular PTP targets.". Methods. 35 (1): 44–53. PMID 15588985. doi:10.1016/j.ymeth.2004.07.007.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. PMID 16303743. doi:10.1093/dnares/12.2.117.
He G, Liu X, Qin W, et al. (2006). "MPZL1/PZR, a novel candidate predisposing schizophrenia in Han Chinese.". Mol. Psychiatry. 11 (8): 748–51. PMID 16702974. doi:10.1038/sj.mp.4001841.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature. 441 (7091): 315–21. PMID 16710414. doi:10.1038/nature04727.

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MPZL1

References

Further reading