MLF1IP

CENPU

Identifiers

CENPU, CENP50, CENPU50, KLIP1, MLF1IP, PBIP1, centromere protein U

External IDs

MGI: 1919126 HomoloGene: 11629 GeneCards: CENPU

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	No data available	Start	184,694,618 bp^[1]
Band	No data available	End	184,734,133 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	No data available	Start	46,552,028 bp^[2]
Band	No data available	End	46,580,007 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• protein binding
Cellular component	• chromosome • cytoplasm • condensed chromosome kinetochore • cytosol • chromosome, centromeric region • nucleus • kinetochore • nucleoplasm • microtubule organizing center
Biological process	• chordate embryonic development • viral process • regulation of transcription, DNA-templated • CENP-A containing nucleosome assembly • transcription, DNA-templated • sister chromatid cohesion
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


79682


71876

Ensembl


ENSG00000151725


ENSMUSG00000031629

UniProt


Q71F23


Q8C4M7

RefSeq (mRNA)


NM_024629


NM_027973

RefSeq (protein)


NP_078905


NP_082249

Location (UCSC)

Chr 4: 184.69 – 184.73 Mb

Chr 4: 46.55 – 46.58 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Centromere protein U is a protein that in humans is encoded by the MLF1IP gene.^[5]^[6]^[7]^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000151725 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031629 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Hanissian SH, Akbar U, Teng B, Janjetovic Z, Hoffmann A, Hitzler JK, Iscove N, Hamre K, Du X, Tong Y, Mukatira S, Robertson JH, Morris SW (Apr 2004). "cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP". Oncogene. 23 (20): 3700–7. PMID 15116101. doi:10.1038/sj.onc.1207448.
↑ Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nat Cell Biol. 8 (5): 446–57. PMID 16622420. doi:10.1038/ncb1396.
↑ Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nat Cell Biol. 8 (5): 458–69. PMID 16622419. doi:10.1038/ncb1397.
↑ "Entrez Gene: MLF1IP MLF1 interacting protein".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. doi:10.1101/gr.6.9.791.
Zhang YJ, Pan HY, Gao SJ (2002). "Reverse transcription slippage over the mRNA secondary structure of the LIP1 gene.". BioTechniques. 31 (6): 1286, 1288, 1290, passim. PMID 11768657.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Pan HY, Zhang YJ, Wang XP, et al. (2003). "Identification of a Novel Cellular Transcriptional Repressor Interacting with the Latent Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus". J. Virol. 77 (18): 9758–68. PMC 224565 . PMID 12941884. doi:10.1128/JVI.77.18.9758-9768.2003.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. PMID 15009096. doi:10.1111/j.1365-2443.2004.00705.x.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Hanissian SH, Teng B, Akbar U, et al. (2005). "Regulation of myeloid leukemia factor-1 interacting protein (MLF1IP) expression in glioblastoma". Brain Res. 1047 (1): 56–64. PMID 15893739. doi:10.1016/j.brainres.2005.04.017.
Minoshima Y, Hori T, Okada M, et al. (2005). "The Constitutive Centromere Component CENP-50 Is Required for Recovery from Spindle Damage". Mol. Cell. Biol. 25 (23): 10315–28. PMC 1291240 . PMID 16287847. doi:10.1128/MCB.25.23.10315-10328.2005.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. PMC 1459365 . PMID 16565220. doi:10.1073/pnas.0507066103.
Izuta H, Ikeno M, Suzuki N, et al. (2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes Cells. 11 (6): 673–84. PMID 16716197. doi:10.1111/j.1365-2443.2006.00969.x.
Kang YH, Park JE, Yu LR, et al. (2006). "Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation". Mol. Cell. 24 (3): 409–22. PMID 17081991. doi:10.1016/j.molcel.2006.10.016.
Suzuki H, Arakawa Y, Ito M, et al. (2007). "MLF1-interacting protein is mainly localized in nucleolus through N-terminal bipartite nuclear localization signal". Anticancer Res. 27 (3B): 1423–30. PMID 17595757.

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MLF1IP

References

Further reading