MIR222
MicroRNA 222 is a MicroRNA that in humans is encoded by the MIR222 gene, and is a know extracellular RNA (exRNA).[3]
Function
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.
References
Further reading
- Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP (March 2003). "Vertebrate microRNA genes". Science. 299 (5612): 1540. PMID 12624257. doi:10.1126/science.1080372.
- Zhang C, Wang G, Kang C, Du Y, Pu P (December 2009). "[Up-regulation of p27(kip1) by miR-221/222 antisense oligonucleotides enhances the radiosensitivity of U251 glioblastoma]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics. 26 (6): 634–8. PMID 19953484. doi:10.3760/cma.j.issn.1003-9406.2009.06.006 (inactive 2017-01-15).
- Hussein K, Theophile K, Büsche G, Schlegelberger B, Göhring G, Kreipe H, Bock O (March 2010). "Significant inverse correlation of microRNA-150/MYB and microRNA-222/p27 in myelodysplastic syndrome". Leukemia Research. 34 (3): 328–34. PMID 19615744. doi:10.1016/j.leukres.2009.06.014.
- Lin D, Cui F, Bu Q, Yan C (2011). "The expression and clinical significance of GTP-binding RAS-like 3 (ARHI) and microRNA 221 and 222 in prostate cancer". The Journal of International Medical Research. 39 (5): 1870–5. PMID 22117988.
- Zhang Y, Ma T, Yang S, Xia M, Xu J, An H, Yang Y, Li S (November 2011). "High-mobility group A1 proteins enhance the expression of the oncogenic miR-222 in lung cancer cells". Molecular and Cellular Biochemistry. 357 (1–2): 363–71. PMID 21656127. doi:10.1007/s11010-011-0907-1.
- Acunzo M, Visone R, Romano G, Veronese A, Lovat F, Palmieri D, Bottoni A, Garofalo M, Gasparini P, Condorelli G, Chiariello M, Croce CM (February 2012). "miR-130a targets MET and induces TRAIL-sensitivity in NSCLC by downregulating miR-221 and 222". Oncogene. 31 (5): 634–42. PMC 3719419
. PMID 21706050. doi:10.1038/onc.2011.260.
- Zhang C, Zhang J, Zhang A, Wang Y, Han L, You Y, Pu P, Kang C (December 2010). "PUMA is a novel target of miR-221/222 in human epithelial cancers". International Journal of Oncology. 37 (6): 1621–6. PMID 21042732. doi:10.3892/ijo_00000816.
- Koelz M, Lense J, Wrba F, Scheffler M, Dienes HP, Odenthal M (February 2011). "Down-regulation of miR-221 and miR-222 correlates with pronounced Kit expression in gastrointestinal stromal tumors". International Journal of Oncology. 38 (2): 503–11. PMID 21132270. doi:10.3892/ijo.2010.857.
- Zhang J, Han L, Ge Y, Zhou X, Zhang A, Zhang C, Zhong Y, You Y, Pu P, Kang C (April 2010). "miR-221/222 promote malignant progression of glioma through activation of the Akt pathway". International Journal of Oncology. 36 (4): 913–20. PMID 20198336. doi:10.3892/ijo_00000570.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
