MGAT5

MGAT5
Identifiers
AliasesMGAT5, GNT-V, GNT-VA, mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
External IDsMGI: 894701 HomoloGene: 1808 GeneCards: MGAT5
Gene location (Human)
Chr.Chromosome 2 (human)[1]
BandNo data availableStart134,119,983 bp[1]
End134,454,621 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4249

107895

Ensembl

ENSG00000152127

ENSMUSG00000036155

UniProt

Q09328

Q8R4G6

RefSeq (mRNA)

NM_002410

NM_145128

RefSeq (protein)

NP_002401

NP_660110

Location (UCSC)Chr 2: 134.12 – 134.45 MbChr 2: 127.21 – 127.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A is an enzyme that in humans is encoded by the MGAT5 gene.[5][6]

This gene encodes mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, a glycosyltransferase involved in the synthesis of protein-bound and lipid-bound oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the encoded protein's activity may correlate with the progression of invasive malignancies.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000152127 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036155 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Saito H, Nishikawa A, Gu J, Ihara Y, Soejima H, Wada Y, Sekiya C, Niikawa N, Taniguchi N (Feb 1994). "cDNA cloning and chromosomal mapping of human N-acetylglucosaminyltransferase V+". Biochem Biophys Res Commun. 198 (1): 318–27. PMID 8292036. doi:10.1006/bbrc.1994.1045.
  6. 1 2 "Entrez Gene: MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase".

Further reading

  • Dennis JW, Granovsky M, Warren CE (2000). "Glycoprotein glycosylation and cancer progression.". Biochim. Biophys. Acta. 1473 (1): 21–34. PMID 10580127. doi:10.1016/s0304-4165(99)00167-1. 
  • Buckhaults P, Chen L, Fregien N, Pierce M (1997). "Transcriptional regulation of N-acetylglucosaminyltransferase V by the src oncogene.". J. Biol. Chem. 272 (31): 19575–81. PMID 9235963. doi:10.1074/jbc.272.31.19575. 
  • Park C, Jin UH, Lee YC, et al. (1999). "Characterization of UDP-N-acetylglucosamine:alpha-6-d-mannoside beta-1,6-N-acetylglucosaminyltransferase V from a human hepatoma cell line Hep3B.". Arch. Biochem. Biophys. 367 (2): 281–8. PMID 10395745. doi:10.1006/abbi.1999.1252. 
  • Granovsky M, Fata J, Pawling J, et al. (2000). "Suppression of tumor growth and metastasis in Mgat5-deficient mice.". Nat. Med. 6 (3): 306–12. PMID 10700233. doi:10.1038/73163. 
  • Ihara S, Miyoshi E, Ko JH, et al. (2002). "Prometastatic effect of N-acetylglucosaminyltransferase V is due to modification and stabilization of active matriptase by adding beta 1-6 GlcNAc branching.". J. Biol. Chem. 277 (19): 16960–7. PMID 11864986. doi:10.1074/jbc.M200673200. 
  • Saito T, Miyoshi E, Sasai K, et al. (2002). "A secreted type of beta 1,6-N-acetylglucosaminyltransferase V (GnT-V) induces tumor angiogenesis without mediation of glycosylation: a novel function of GnT-V distinct from the original glycosyltransferase activity.". J. Biol. Chem. 277 (19): 17002–8. PMID 11872751. doi:10.1074/jbc.M200521200. 
  • Dosaka-Akita H, Miyoshi E, Suzuki O, et al. (2004). "Expression of N-acetylglucosaminyltransferase v is associated with prognosis and histology in non-small cell lung cancers.". Clin. Cancer Res. 10 (5): 1773–9. PMID 15014031. doi:10.1158/1078-0432.CCR-1047-3. 
  • Guo P, Zhang Y, Shen ZH, et al. (2004). "Effect of N-acetylglucosaminyltransferase V on the expressions of other glycosyltransferases.". FEBS Lett. 562 (1-3): 93–8. PMID 15044007. doi:10.1016/S0014-5793(04)00188-7. 
  • Kim CH (2005). "Increased expression of N-acetylglucosaminyltransferase-V in human hepatoma cells by retinoic acid and 1alpha,25-dihydroxyvitamin D3.". Int. J. Biochem. Cell Biol. 36 (11): 2307–19. PMID 15313475. doi:10.1016/j.biocel.2004.04.021. 
  • Tomiie M, Isaka S, Miyoshi E, et al. (2005). "Elevated expression of N-acetylglucosaminyltransferase V in first trimester human placenta.". Biochem. Biophys. Res. Commun. 330 (3): 999–1004. PMID 15809094. doi:10.1016/j.bbrc.2005.02.186. 
  • Fang H, Huang W, Xu YY, et al. (2006). "Blocking of N-acetylglucosaminyltransferase V induces cellular endoplasmic reticulum stress in human hepatocarcinoma 7,721 cells.". Cell Res. 16 (1): 82–92. PMID 16467879. doi:10.1038/sj.cr.7310011. 
  • Ishimura H, Takahashi T, Nakagawa H, et al. (2006). "N-acetylglucosaminyltransferase V and beta1-6 branching N-linked oligosaccharides are associated with good prognosis of patients with bladder cancer.". Clin. Cancer Res. 12 (8): 2506–11. PMID 16638859. doi:10.1158/1078-0432.CCR-05-1938. 
  • Wang L, Liang Y, Li Z, et al. (2007). "Increase in beta1-6 GlcNAc branching caused by N-acetylglucosaminyltransferase V directs integrin beta1 stability in human hepatocellular carcinoma cell line SMMC-7721.". J. Cell. Biochem. 100 (1): 230–41. PMID 16924681. doi:10.1002/jcb.21071. 
  • Li J, Wang XM, Wang Q, et al. (2007). "Down-regulation of N-acetylglucosaminyltransferase-V induces ER stress by changing glycosylation and function of GLUT1.". Arch. Biochem. Biophys. 463 (1): 102–9. PMID 17451637. doi:10.1016/j.abb.2007.03.005. 
  • Kudo T, Nakagawa H, Takahashi M, et al. (2007). "N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma.". Mol. Cancer. 6 (1): 32. PMC 1878497 Freely accessible. PMID 17488527. doi:10.1186/1476-4598-6-32. 


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