MAP3K1

MAP3K1
Identifiers
Aliases	MAP3K1, MAPKKK1, MEKK, MEKK 1, MEKK1, SRXY6, mitogen-activated protein kinase kinase kinase 1
External IDs	MGI: 1346872 HomoloGene: 8056 GeneCards: MAP3K1
Gene location (Human) Chr. Chromosome 5 (human)[1] Band No data available Start 56,815,574 bp[1] End 56,896,152 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band No data available Start 111,746,428 bp[2] End 111,808,993 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • zinc ion binding • metal ion binding • kinase activity • protein binding • MAP kinase kinase kinase activity • ATP binding • protein kinase binding • protein kinase activity • protein serine/threonine kinase activity Cellular component • cytoplasm • cytosol Biological process • phosphorylation • MyD88-dependent toll-like receptor signaling pathway • Fc-epsilon receptor signaling pathway • protein phosphorylation • cellular response to mechanical stimulus • MAPK cascade • activation of MAPKK activity • regulation of mitotic cell cycle • signal transduction by protein phosphorylation • stress-activated protein kinase signaling cascade • activation of protein kinase activity • regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4214	26401
Ensembl	ENSG00000095015	ENSMUSG00000021754
UniProt	Q13233	P53349
RefSeq (mRNA)	NM_005921	NM_011945
RefSeq (protein)	NP_005912	n/a
Location (UCSC)	Chr 5: 56.82 – 56.9 Mb	Chr 5: 111.75 – 111.81 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Mitogen-activated protein kinase kinase kinase 1 is an enzyme that in humans is encoded by the MAP3K1 gene.^[5][6]

Function

MAP3K, or MEK kinase, is a serine/threonine kinase that occupies a pivotal role in a network of phosphorylating enzymes integrating cellular responses to a number of mitogenic and metabolic stimuli, including insulin and many growth factors.^[6]

Mouse genetics has revealed that the kinase is important in: correct embryogenesis, keratinocyte migration, T cell cytokine production and B cell antibody production.

Interactions

MAP3K1 has been shown to interact with:

• AXIN1,^[7][8]
• C-Raf,^[9]
• Grb2,^[10]
• MAP2K1,^[9]
• MAPK1,^[9]
• MAPK8,^[11]
• TRAF2,^[12] and
• UBE2I.^[13]

References

Further reading