MCF2L

MCF2L
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMCF2L, ARHGEF14, DBS, OST, MCF.2 cell line derived transforming sequence like
External IDsMGI: 103263 HomoloGene: 11804 GeneCards: MCF2L
Gene location (Human)
Chr.Chromosome 13 (human)[1]
BandNo data availableStart112,894,378 bp[1]
End113,099,739 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

23263

17207

Ensembl

ENSG00000126217

ENSMUSG00000031442

UniProt

O15068

Q64096

RefSeq (mRNA)

NM_001112732
NM_024979
NM_001320815
NM_001320816
NM_001320817

NM_001159485
NM_001159486
NM_178076

RefSeq (protein)

NP_001106203
NP_001307744
NP_001307745
NP_001307746
NP_079255

n/a

Location (UCSC)Chr 13: 112.89 – 113.1 MbChr 13: 12.87 – 13.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Guanine nucleotide exchange factor DBS is a protein that in humans is encoded by the MCF2L gene.[5][6]

Model organisms

Model organisms have been used in the study of MCF2L function. A conditional knockout mouse line called Mcf2ltm1a(EUCOMM)Hmgu was generated at the Wellcome Trust Sanger Institute.[7] Male and female animals underwent a standardized phenotypic screen[8] to determine the effects of deletion.[9][10][11][12] Additional screens performed: - In-depth immunological phenotyping[13]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000126217 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031442 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 4 (2): 141–50. PMID 9205841. doi:10.1093/dnares/4.2.141.
  6. ↑ "Entrez Gene: MCF2L MCF.2 cell line derived transforming sequence-like".
  7. ↑ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  8. 1 2 "International Mouse Phenotyping Consortium".
  9. ↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. PMC 3572410 Freely accessible. PMID 21677750. doi:10.1038/nature10163.
  10. ↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. PMID 21677718. doi:10.1038/474262a.
  11. ↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. PMID 17218247. doi:10.1016/j.cell.2006.12.018.
  12. ↑ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. PMC 3717207 Freely accessible. PMID 23870131. doi:10.1016/j.cell.2013.06.022.
  13. 1 2 "Infection and Immunity Immunophenotyping (3i) Consortium".

Further reading


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