MAPK7

MAPK7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Q8Y, 4B99, 4IC7, 4IC8, 4ZSJ, 4ZSL, 5BYZ, 5BYY, 4ZSG
Identifiers
Aliases	MAPK7, BMK1, ERK4, ERK5, PRKM7, mitogen-activated protein kinase 7
External IDs	MGI: 1346347 HomoloGene: 2060 GeneCards: MAPK7
Gene location (Human) Chr. Chromosome 17 (human)[1] Band No data available Start 19,377,721 bp[1] End 19,383,544 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band No data available Start 61,488,812 bp[2] End 61,494,406 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • mitogen-activated protein kinase binding • kinase activity • protein binding • ATP binding • protein serine/threonine kinase activity • MAP kinase activity Cellular component • cytoplasm • cytosol • PML body • nucleoplasm • nucleus Biological process • cellular response to transforming growth factor beta stimulus • negative regulation of endothelial cell apoptotic process • cell differentiation • phosphorylation • negative regulation of cAMP catabolic process • negative regulation of ERK5 cascade • cellular response to laminar fluid shear stress • positive regulation of transcription from RNA polymerase II promoter in response to stress • cellular response to growth factor stimulus • negative regulation of apoptotic process • regulation of angiogenesis • negative regulation of response to cytokine stimulus • positive regulation of protein metabolic process • protein phosphorylation • negative regulation of NFAT protein import into nucleus • negative regulation of MAP kinase activity • peptidyl-serine phosphorylation • cell cycle • negative regulation of cyclic-nucleotide phosphodiesterase activity • negative regulation of heterotypic cell-cell adhesion • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • negative regulation of inflammatory response • cAMP-mediated signaling • signal transduction • positive regulation of transcription from RNA polymerase II promoter • cellular response to hydrogen peroxide • MAPK cascade • axon guidance Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5598	23939
Ensembl	ENSG00000166484	ENSMUSG00000001034
UniProt	Q13164	Q9WVS8
RefSeq (mRNA)	NM_002749 NM_139032 NM_139033 NM_139034	NM_001291033 NM_001291034 NM_001291035 NM_001291036 NM_001291037 NM_011841
RefSeq (protein)	NP_002740 NP_620601 NP_620602 NP_620603	NP_001277962 NP_001277963 NP_001277964 NP_001277965 NP_001277966 NP_035971
Location (UCSC)	Chr 17: 19.38 – 19.38 Mb	Chr 17: 61.49 – 61.49 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Mitogen-activated protein kinase 7 also known as MAP kinase 7 is an enzyme that in humans is encoded by the MAPK7 gene.^[5][6]

Function

MAPK7 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor tyrosine kinases, and G protein-coupled receptors. In response to extracellular signals, this kinase translocates to the cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.^[7]

MAPK7 is also critical for cardiovascular development ^[8] and is essential for endothelial cell function.^[9][10]

Interactions

MAPK7 has been shown to interact with:

References

Further reading

External links

• MAP Kinase Resource .