MAP3K9

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3DTC, 4UY9

Identifiers

Aliases

MAP3K9, MEKK9, MLK1, PRKE1, mitogen-activated protein kinase kinase kinase 9

External IDs

MGI: 2449952 HomoloGene: 76377 GeneCards: MAP3K9

Gene location (Human)

Chr.	Chromosome 14 (human)^[1]

Band	No data available	Start	70,722,526 bp^[1]
Band	No data available	End	70,809,534 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[2]

Band	No data available	Start	81,721,010 bp^[2]
Band	No data available	End	81,781,175 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• transferase activity • nucleotide binding • protein kinase activity • protein homodimerization activity • kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding • MAP kinase kinase kinase activity • MAP kinase kinase activity • JUN kinase kinase kinase activity
Cellular component	• cytoplasm
Biological process	• regulation of transcription, DNA-templated • phosphorylation • activation of MAPKK activity • cell death • transcription, DNA-templated • protein phosphorylation • positive regulation of apoptotic process • protein autophosphorylation • apoptotic process • activation of JNKK activity • activation of JUN kinase activity
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


4293


338372

Ensembl


ENSG00000006432


ENSMUSG00000042724

UniProt


P80192


Q3U1V8

RefSeq (mRNA)


NM_001284230 NM_001284231 NM_001284232 NM_033141


NM_001174107 NM_177395

RefSeq (protein)


NP_001271159 NP_001271160 NP_001271161 NP_149132


NP_001167578 NP_796369

Location (UCSC)

Chr 14: 70.72 – 70.81 Mb

Chr 14: 81.72 – 81.78 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Mitogen-activated protein kinase kinase kinase 9 is an enzyme that in humans is encoded by the MAP3K9 gene.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000006432 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042724 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: MAP3K9 mitogen-activated protein kinase kinase kinase 9".

Gallo KA, Mark MR, Scadden DT, et al. (1994). "Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity.". J. Biol. Chem. 269 (21): 15092–100. PMID 8195146.
Dorow DS, Devereux L, Dietzsch E, De Kretser T (1993). "Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains.". Eur. J. Biochem. 213 (2): 701–10. PMID 8477742. doi:10.1111/j.1432-1033.1993.tb17810.x.
Dorow DS, Devereux L, Tu GF, et al. (1996). "Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2.". Eur. J. Biochem. 234 (2): 492–500. PMID 8536694. doi:10.1111/j.1432-1033.1995.492_b.x.
Xu Z, Maroney AC, Dobrzanski P, et al. (2001). "The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis.". Mol. Cell. Biol. 21 (14): 4713–24. PMC 87148 . PMID 11416147. doi:10.1128/MCB.21.14.4713-4724.2001.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Figueroa C, Tarras S, Taylor J, Vojtek AB (2004). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex.". J. Biol. Chem. 278 (48): 47922–7. PMID 14504284. doi:10.1074/jbc.M307357200.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Durkin JT, Holskin BP, Kopec KK, et al. (2005). "Phosphoregulation of mixed-lineage kinase 1 activity by multiple phosphorylation in the activation loop.". Biochemistry. 43 (51): 16348–55. PMID 15610029. doi:10.1021/bi049866y.

Kinases: Serine/threonine-specific protein kinases (EC 2.7.11-12)

Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)

Non-specific serine/threonine protein kinases (EC 2.7.11.1)	LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated Mammalian target of rapamycin EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1
Pyruvate dehydrogenase kinase (EC 2.7.11.2)	PDK1 PDK2 PDK3
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)	AMP-activated protein kinase α PRKAA1 PRKAA2 β PRKAB1 PRKAB2 γ PRKAG1 PRKAG2 PRKAG3
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)	BCKDK BCKDHA BCKDHB
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)	IDH2 IDH3A IDH3B IDH3G
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)	STK4
Myosin-heavy-chain kinase (EC 2.7.11.7)	Aurora kinase Aurora A kinase Aurora B kinase
Fas-activated serine/threonine kinase (EC 2.7.11.8)	FASTK STK10
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)	-
IκB kinase (EC 2.7.11.10)	CHUK IKK2 TBK1 IKBKE IKBKG IKBKAP
cAMP-dependent protein kinase (EC 2.7.11.11)	Protein kinase A PRKACG PRKACB PRKACA PRKY
cGMP-dependent protein kinase (EC 2.7.11.12)	Protein kinase G PRKG1
Protein kinase C (EC 2.7.11.13)	Protein kinase C Protein kinase Cζ PKC alpha PRKCB1 PRKCD PRKCE PRKCH PRKCG PRKCI PRKCQ Protein kinase N1 PKN2 PKN3
Rhodopsin kinase (EC 2.7.11.14)	Rhodopsin kinase
Beta adrenergic receptor kinase (EC 2.7.11.15)	Beta adrenergic receptor kinase Beta adrenergic receptor kinase-2
G-protein coupled receptor kinases (EC 2.7.11.16)	GRK4 GRK5 GRK6
Ca2+/calmodulin-dependent (EC 2.7.11.17)	BRSK2 CAMK1 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 MLCK CASK CHEK1 CHEK2 DAPK1 DAPK2 DAPK3 STK11 MAPKAPK2 MAPKAPK3 MAPKAPK5 MARK1 MARK2 MARK3 MARK4 MELK MKNK1 MKNK2 NUAK1 NUAK2 OBSCN PASK PHKG1 PHKG2 PIM1 PIM2 PKD1 PRKD2 PRKD3 PSKH1 SNF1LK2 KIAA0999 STK40 SNF1LK SNRK SPEG TSSK2 Kalirin TRIB1 TRIB2 TRIB3 TRIO Titin DCLK1
Myosin light-chain kinase (EC 2.7.11.18)	MYLK MYLK2 MYLK3 MYLK4
Phosphorylase kinase (EC 2.7.11.19)	PHKA1 PHKA2 PHKB PHKG1 PHKG2
Elongation factor 2 kinase (EC 2.7.11.20)	EEF2K STK19
Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4

Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)

Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4
Cyclin-dependent kinase (EC 2.7.11.22)	CDK1 CDK2 CDKL2 CDK3 CDK4 CDK5 CDKL5 CDK6 CDK7 CDK8 CDK9 CDK10 CDK12 CDC2L5 PCTK1 PCTK2 PCTK3 PFTK1 CDC2L1
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)	RPS6KA5 RPS6KA4 P70S6 kinase P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1
Mitogen-activated protein kinase (EC 2.7.11.24)	Extracellular signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14
MAP3K (EC 2.7.11.25)	MAP kinase kinase kinases MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAP3K8 RAFs ARAF BRAF KSR1 KSR2 MLKs MAP3K12 MAP3K13 MAP3K9 MAP3K10 MAP3K11 MAP3K7 ZAK CDC7 MAP3K14
Tau-protein kinase (EC 2.7.11.26)	TPK1 TTK GSK-3
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)	-
Tropomyosin kinase (EC 2.7.11.28)	-
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)	-
Receptor protein serine/threonine kinase (EC 2.7.11.30)	Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

Dual-specificity kinases (EC 2.7.12)

MAP2K	MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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MAP3K9

References

Further reading