MAP3K2

MAP3K2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMAP3K2, MEKK2, MEKK2B, mitogen-activated protein kinase kinase kinase 2
External IDsMGI: 1346873 HomoloGene: 74576 GeneCards: MAP3K2
Gene location (Human)
Chr.Chromosome 2 (human)[1]
BandNo data availableStart127,298,730 bp[1]
End127,388,465 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10746

26405

Ensembl

ENSG00000169967

ENSMUSG00000024383

UniProt

Q9Y2U5

Q61083

RefSeq (mRNA)

NM_006609

NM_011946

RefSeq (protein)

NP_006600

NP_036076

Location (UCSC)Chr 2: 127.3 – 127.39 MbChr 2: 32.16 – 32.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mitogen-activated protein kinase kinase kinase 2 is an enzyme that in humans is encoded by the MAP3K2 gene.[5][6][7]

Function

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate IkappaB kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process.[7]

Interactions

MAP3K2 has been shown to interact with:

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000169967 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024383 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Blank JL, Gerwins P, Elliott EM, Sather S, Johnson GL (Mar 1996). "Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase". The Journal of Biological Chemistry. 271 (10): 5361–8. PMID 8621389. doi:10.1074/jbc.271.10.5361.
  6. ↑ Zhao Q, Lee FS (Mar 1999). "Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta". The Journal of Biological Chemistry. 274 (13): 8355–8. PMID 10085062. doi:10.1074/jbc.274.13.8355.
  7. 1 2 "Entrez Gene: MAP3K2 mitogen-activated protein kinase kinase kinase 2".
  8. 1 2 Sun W, Kesavan K, Schaefer BC, Garrington TP, Ware M, Johnson NL, Gelfand EW, Johnson GL (Feb 2001). "MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway". The Journal of Biological Chemistry. 276 (7): 5093–100. PMID 11073940. doi:10.1074/jbc.M003719200.
  9. 1 2 Cheng J, Yang J, Xia Y, Karin M, Su B (Apr 2000). "Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation". Molecular and Cellular Biology. 20 (7): 2334–42. PMC 85399 Freely accessible. PMID 10713157. doi:10.1128/mcb.20.7.2334-2342.2000.
  10. ↑ Winsauer G, Resch U, Hofer-Warbinek R, Schichl YM, de Martin R (Nov 2008). "XIAP regulates bi-phasic NF-kappaB induction involving physical interaction and ubiquitination of MEKK2". Cellular Signalling. 20 (11): 2107–12. PMID 18761086. doi:10.1016/j.cellsig.2008.08.004.

Further reading

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