MAP2K1IP1

LAMTOR3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1SKO, 2ZL1, 3CPT

Identifiers

Aliases

LAMTOR3, MAP2K1IP1, MAPBP, MAPKSP1, MP1, PRO0633, Ragulator3, late endosomal/lysosomal adaptor, MAPK and MTOR activator 3

External IDs

MGI: 1929467 HomoloGene: 10539 GeneCards: LAMTOR3

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	No data available	Start	99,878,336 bp^[1]
Band	No data available	End	99,894,490 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	No data available	Start	137,918,506 bp^[2]
Band	No data available	End	137,928,900 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• guanyl-nucleotide exchange factor activity • protein binding • protein complex scaffold activity • kinase activator activity
Cellular component	• endosome • membrane • late endosome membrane • focal adhesion • Ragulator complex • lysosomal membrane • endosome membrane • extracellular exosome • late endosome • plasma membrane • specific granule membrane • tertiary granule membrane
Biological process	• regulation of TOR signaling • MAPK cascade • cellular protein localization • cell cycle arrest • cellular response to amino acid stimulus • positive regulation of TOR signaling • activation of MAPKK activity • positive regulation of GTPase activity • neutrophil degranulation • regulation of macroautophagy
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


8649


56692

Ensembl


ENSG00000109270


ENSMUSG00000091512

UniProt


Q9UHA4


O88653

RefSeq (mRNA)


NM_001243736 NM_021970


NM_019920

RefSeq (protein)


NP_001230665 NP_068805


NP_064304

Location (UCSC)

Chr 4: 99.88 – 99.89 Mb

Chr 4: 137.92 – 137.93 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Mitogen-activated protein kinase scaffold protein 1 is a scaffold protein that in humans is encoded by the MAPKSP1 gene.^[5]^[6]^[7]

Function

The protein encoded by this gene was identified as an interacting protein that binds specifically to MAP kinase kinase MAP2K1/MEK1 and to MAP kinase MAPK2/ERK1. This protein enhances the activation of MAPK2, and thus is thought to function as an adaptor to enhance the efficiency of the MAP kinase cascade.^[7]

Interactions

MAP2K1IP1 has been shown to interact with MAP2K1.^[5]^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000109270 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000091512 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 Schaeffer HJ, Catling AD, Eblen ST, Collier LS, Krauss A, Weber MJ (Oct 1998). "MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade". Science. 281 (5383): 1668–71. PMID 9733512. doi:10.1126/science.281.5383.1668.
↑ Lunin VV, Munger C, Wagner J, Ye Z, Cygler M, Sacher M (May 2004). "The structure of the MAPK scaffold, MP1, bound to its partner, p14. A complex with a critical role in endosomal map kinase signaling". J. Biol. Chem. 279 (22): 23422–30. PMID 15016825. doi:10.1074/jbc.M401648200.
1 2 "Entrez Gene: MAP2K1IP1 mitogen-activated protein kinase kinase 1 interacting protein 1".
↑ Wunderlich W, Fialka I, Teis D, Alpi A, Pfeifer A, Parton RG, Lottspeich F, Huber LA (Feb 2001). "A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment". J. Cell Biol. 152 (4): 765–76. PMC 2195784 . PMID 11266467. doi:10.1083/jcb.152.4.765.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1-2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
Okabe S, Tauchi T, Morita H, Ohashi H, Yoshimura A, Ohyashiki K (1999). "Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway". Exp. Hematol. 27 (10): 1542–7. PMID 10517496. doi:10.1016/S0301-472X(99)00094-6.
Wunderlich W, Fialka I, Teis D, Alpi A, Pfeifer A, Parton RG, Lottspeich F, Huber LA (2001). "A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment". J. Cell Biol. 152 (4): 765–76. PMC 2195784 . PMID 11266467. doi:10.1083/jcb.152.4.765.
Teis D, Wunderlich W, Huber LA (2002). "Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction". Dev. Cell. 3 (6): 803–14. PMID 12479806. doi:10.1016/S1534-5807(02)00364-7.
Channavajhala PL, Wu L, Cuozzo JW, Hall JP, Liu W, Lin LL, Zhang Y (2003). "Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling". J. Biol. Chem. 278 (47): 47089–97. PMID 12975377. doi:10.1074/jbc.M306002200.
Paces-Fessy M, Boucher D, Petit E, Paute-Briand S, Blanchet-Tournier MF (2004). "The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins". Biochem. J. 378 (Pt 2): 353–62. PMC 1223961 . PMID 14611647. doi:10.1042/BJ20030786.
Vomastek T, Schaeffer HJ, Tarcsafalvi A, Smolkin ME, Bissonette EA, Weber MJ (2004). "Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists". Proc. Natl. Acad. Sci. U.S.A. 101 (18): 6981–6. PMC 406452 . PMID 15118098. doi:10.1073/pnas.0305894101.
Kurzbauer R, Teis D, de Araujo ME, Maurer-Stroh S, Eisenhaber F, Bourenkov GP, Bartunik HD, Hekman M, Rapp UR, Huber LA, Clausen T (2004). "Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes". Proc. Natl. Acad. Sci. U.S.A. 101 (30): 10984–9. PMC 503730 . PMID 15263099. doi:10.1073/pnas.0403435101.
Sharma C, Vomastek T, Tarcsafalvi A, Catling AD, Schaeffer HJ, Eblen ST, Weber MJ (2005). "MEK partner 1 (MP1): regulation of oligomerization in MAP kinase signaling". J. Cell. Biochem. 94 (4): 708–19. PMID 15547943. doi:10.1002/jcb.20344.
Pullikuth A, McKinnon E, Schaeffer HJ, Catling AD (2005). "The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals". Mol. Cell. Biol. 25 (12): 5119–33. PMC 1140582 . PMID 15923628. doi:10.1128/MCB.25.12.5119-5133.2005.
Villegas SN, Njaine B, Linden R, Carri NG (2006). "Glial-derived neurotrophic factor (GDNF) prevents ethanol (EtOH) induced B92 glial cell death by both PI3K/AKT and MEK/ERK signaling pathways". Brain Res. Bull. 71 (1-3): 116–26. PMID 17113937. doi:10.1016/j.brainresbull.2006.08.014.
Teis D, Taub N, Kurzbauer R, Hilber D, de Araujo ME, Erlacher M, Offterdinger M, Villunger A, Geley S, Bohn G, Klein C, Hess MW, Huber LA (2006). "p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis". J. Cell Biol. 175 (6): 861–8. PMC 2064696 . PMID 17178906. doi:10.1083/jcb.200607025.
Brahma A, Dalby KN (2007). "Regulation of protein phosphorylation within the MKK1-ERK2 complex by MP1 and the MP1*P14 heterodimer". Arch. Biochem. Biophys. 460 (1): 85–91. PMC 2853909 . PMID 17254543. doi:10.1016/j.abb.2006.11.031.
Vomastek T, Iwanicki MP, Schaeffer HJ, Tarcsafalvi A, Parsons JT, Weber MJ (2007). "RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility". Mol. Cell. Biol. 27 (23): 8296–305. PMC 2169169 . PMID 17908799. doi:10.1128/MCB.00598-07.

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MAP2K1IP1

Function

Interactions

References

Further reading