MAP1B

Identifiers

MAP1B, FUTSCH, MAP5, PPP1R102, microtubule-associated protein 1B, microtubule associated protein 1B

External IDs

MGI: 1306778 HomoloGene: 38111 GeneCards: MAP1B

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	No data available	Start	72,107,234 bp^[1]
Band	No data available	End	72,209,570 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 13 (mouse)^[2]

Band	No data available	Start	99,421,464 bp^[2]
Band	No data available	End	99,516,602 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• microtubule binding • structural molecule activity • protein binding
Cellular component	• cell projection • postsynaptic density of dendrite • plasma membrane • dendritic spine • photoreceptor outer segment • synapse • microtubule associated complex • cell junction • microtubule • cytoskeleton • cytoplasm • cytosol
Biological process	• negative regulation of intracellular transport • axonogenesis • dendrite development • nervous system development • microtubule bundle formation • axon extension • positive regulation of axon extension • mitochondrion transport along microtubule • establishment of monopolar cell polarity • cellular process • microtubule cytoskeleton organization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


4131


17755

Ensembl


ENSG00000131711


ENSMUSG00000052727

UniProt


P46821


P46821 P14873

RefSeq (mRNA)


NM_005909 NM_032010 NM_001324255


NM_008634

RefSeq (protein)


NP_001311184 NP_005900


NP_001311184 NP_005900 NP_032660

Location (UCSC)

Chr 5: 72.11 – 72.21 Mb

Chr 5: 99.42 – 99.52 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Microtubule-associated protein 1B is a protein that in humans is encoded by the MAP1B gene.^[5]^[6]

Function

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. Two alternatively spliced transcript variants have been described.^[6]

Interactions

MAP1B has been shown to interact with Acidic leucine-rich nuclear phosphoprotein 32 family member A^[7] and RASSF1.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000131711 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052727 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Lien LL, Boyce FM, Kleyn P, Brzustowicz LM, Menninger J, Ward DC, Gilliam TC, Kunkel LM (Oct 1991). "Mapping of human microtubule-associated protein 1B in proximity to the spinal muscular atrophy locus at 5q13". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7873–6. PMC 52406 . PMID 1881920. doi:10.1073/pnas.88.17.7873.
1 2 "Entrez Gene: MAP1B microtubule-associated protein 1B".
↑ Opal P, Garcia JJ, Propst F, Matilla A, Orr HT, Zoghbi HY (Sep 2003). "Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis". J. Biol. Chem. 278 (36): 34691–9. PMID 12807913. doi:10.1074/jbc.M302785200.
↑ Dallol A, Agathanggelou A, Fenton SL, Ahmed-Choudhury J, Hesson L, Vos MD, Clark GJ, Downward J, Maher ER, Latif F (Jun 2004). "RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics". Cancer Res. 64 (12): 4112–6. PMID 15205320. doi:10.1158/0008-5472.CAN-04-0267.

Hammarback JA, Obar RA, Hughes SM, Vallee RB (1991). "MAP1B is encoded as a polyprotein that is processed to form a complex N-terminal microtubule-binding domain". Neuron. 7 (1): 129–39. PMID 1712602. doi:10.1016/0896-6273(91)90081-A.
Schoenfeld TA, McKerracher L, Obar R, Vallee RB (1989). "MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS". J. Neurosci. 9 (5): 1712–30. PMID 2470876.
Avila J, Ulloa L, Diez-Guerra J, Diaz-Nido J (1994). "Role of phosphorylated MAPlB in neuritogenesis". Cell Biol. Int. 18 (5): 309–14. PMID 7519512. doi:10.1006/cbir.1994.1079.
Lien LL, Feener CA, Fischbach N, Kunkel LM (1994). "Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15". Genomics. 22 (2): 273–80. PMID 7806212. doi:10.1006/geno.1994.1384.
Ohyu J, Takashima S (1998). "Decreased expression of microtubule-associated protein 5 (MAP5) in the molecular layer of cerebellum in preterm infants with olivocerebellar lesions". Brain Dev. 20 (1): 22–6. PMID 9533556. doi:10.1016/S0387-7604(97)00088-0.
Lucas FR, Goold RG, Gordon-Weeks PR, Salinas PC (1998). "Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium". J. Cell. Sci. 111 ( Pt 10) (10): 1351–61. PMID 9570753.
Tögel M, Wiche G, Propst F (1998). "Novel features of the light chain of microtubule-associated protein MAP1B: microtubule stabilization, self interaction, actin filament binding, and regulation by the heavy chain". J. Cell Biol. 143 (3): 695–707. PMC 2148156 . PMID 9813091. doi:10.1083/jcb.143.3.695.
Hanley JG, Koulen P, Bedford F, Gordon-Weeks PR, Moss SJ (1999). "The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses". Nature. 397 (6714): 66–9. PMID 9892354. doi:10.1038/16258.
Jensen PH, Islam K, Kenney J, Nielsen MS, Power J, Gai WP (2000). "Microtubule-associated protein 1B is a component of cortical Lewy bodies and binds alpha-synuclein filaments". J. Biol. Chem. 275 (28): 21500–7. PMID 10764738. doi:10.1074/jbc.M000099200.
Tanner SL, Franzen R, Jaffe H, Quarles RH (2000). "Evidence for expression of some microtubule-associated protein 1B in neurons as a plasma membrane glycoprotein". J. Neurochem. 75 (2): 553–62. PMID 10899930. doi:10.1046/j.1471-4159.2000.0750553.x.
Mei X, Sweatt AJ, Hammarback JA (2000). "Regulation of microtubule-associated protein 1B (MAP1B) subunit composition". J. Neurosci. Res. 62 (1): 56–64. PMID 11002287. doi:10.1002/1097-4547(20001001)62:1<56::AID-JNR6>3.0.CO;2-#.
Billups D, Hanley JG, Orme M, Attwell D, Moss SJ (2000). "GABAC receptor sensitivity is modulated by interaction with MAP1B". J. Neurosci. 20 (23): 8643–50. PMID 11102469.
Franzen R, Tanner SL, Dashiell SM, Rottkamp CA, Hammer JA, Quarles RH (2001). "Microtubule-associated protein 1B: a neuronal binding partner for myelin-associated glycoprotein". J. Cell Biol. 155 (6): 893–8. PMC 2150906 . PMID 11733546. doi:10.1083/jcb.200108137.
Ding J, Liu JJ, Kowal AS, Nardine T, Bhattacharya P, Lee A, Yang Y (2002). "Microtubule-associated protein 1B: a neuronal binding partner for gigaxonin". J. Cell Biol. 158 (3): 427–33. PMC 2173828 . PMID 12147674. doi:10.1083/jcb.200202055.
Dergunova LV, Raevskaya NM, Vladychenskaya IP, Limborska SA (2003). "Hmob3 brain-specific sequence is a part of phylogenetically conserved human MAP1B gene 3'-untranslated region". Biomol. Eng. 20 (3): 91–6. PMID 12684070. doi:10.1016/S1389-0344(03)00003-0.
Chang L, Jones Y, Ellisman MH, Goldstein LS, Karin M (2003). "JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins". Dev. Cell. 4 (4): 521–33. PMID 12689591. doi:10.1016/S1534-5807(03)00094-7.
Opal P, Garcia JJ, Propst F, Matilla A, Orr HT, Zoghbi HY (2003). "Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis". J. Biol. Chem. 278 (36): 34691–9. PMID 12807913. doi:10.1074/jbc.M302785200.

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MAP1B

Function

Interactions

References

Further reading