Myelin-associated glycoprotein

MAG
Identifiers
Aliases	MAG, GMA, S-SIGLEC-4A, SIGLEC4A, SPG75, myelin associated glycoprotein
External IDs	OMIM: 159460 MGI: 96912 HomoloGene: 1771 GeneCards: MAG
Gene location (Human) Chr. Chromosome 19 (human)[1] Band No data available Start 35,292,125 bp[1] End 35,313,804 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band No data available Start 30,899,176 bp[2] End 30,914,873 bp[2]
Gene ontology Molecular function • receptor binding • lipid binding • protein kinase binding • carbohydrate binding • sialic acid binding • protein homodimerization activity • ganglioside GT1b binding Cellular component • cytoplasm • plasma membrane • integral component of plasma membrane • membrane • integral component of membrane • paranode region of axon • myelin sheath adaxonal region • myelin sheath • compact myelin • Schmidt-Lanterman incisure • membrane raft • mesaxon Biological process • cell adhesion • nervous system development • negative regulation of neuron projection development • substantia nigra development • central nervous system myelination • negative regulation of axon extension • positive regulation of myelination • negative regulation of neuron apoptotic process • negative regulation of neuron differentiation • positive regulation of astrocyte differentiation • negative regulation of axonogenesis • leukocyte migration • cellular response to mechanical stimulus • cell-cell adhesion via plasma-membrane adhesion molecules Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4099	17136
Ensembl	ENSG00000105695	ENSMUSG00000036634
UniProt	P20916	P20917
RefSeq (mRNA)	NM_080600 NM_001199216 NM_002361	NM_010758
RefSeq (protein)	NP_001186145 NP_002352 NP_542167	NP_001333013 NP_001333014 NP_001333015 NP_001333016 NP_001333017 NP_001333018 NP_034888
Location (UCSC)	Chr 19: 35.29 – 35.31 Mb	Chr 19: 30.9 – 30.91 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Myelin-associated glycoprotein (MAG, Siglec-4) is a cell membrane glycoprotein that is a member of the SIGLEC family of proteins and is a functional ligand of the NOGO-66 receptor, NgR.^[5] MAG is believed to be involved in myelination during nerve regeneration.^[6]

See also

• Myelin

External links

• Myelin-associated glycoprotein at the US National Library of Medicine Medical Subject Headings (MeSH)

References

1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000105695 - Ensembl, May 2017
2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036634 - Ensembl, May 2017
3. ↑ "Human PubMed Reference:". 
4. ↑ "Mouse PubMed Reference:". 
5. ↑ Quarles RH (2007). "Myelin-associated glycoprotein (MAG): past, present and beyond". Journal of Neurochemistry. 100 (6): 1431–48. PMID 17241126. doi:10.1111/j.1471-4159.2006.04319.x. 
6. ↑ Barton D, Arquint M, Roder J, Dunn R, Francke U (1987). "The myelin-associated glycoprotein gene: mapping to human chromosome 19 and mouse chromosome 7 and expression in quivering mice". Genomics. 1 (2): 107–12. PMID 2447011. doi:10.1016/0888-7543(87)90002-4.