Luliconazole

Luliconazole
Clinical data


Trade names	Luzu, Lulicon
Routes of administration	Topical
ATC code	D01AC18 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Protein binding	>99%^[1]
Identifiers
IUPAC name (2E)-[(4R)-4-(2,4-Dichlorophenyl)-1,3-dithiolan-2-ylidene](1H-imidazol-1-yl)acetonitrile
CAS Number	187164-19-8
PubChem CID	3003141
ChemSpider	2273807
Chemical and physical data
Formula	C₁₄H₉Cl₂N₃S₂
Molar mass	354.28 g/mol
3D model (JSmol)	Interactive image
SMILES C1[C@H](S/C(=C(\C#N)/N2C=CN=C2)/S1)C3=C(C=C(C=C3)Cl)Cl
InChI InChI=1S/C14H9Cl2N3S2/c15-9-1-2-10(11(16)5-9)13-7-20-14(21-13)12(6-17)19-4-3-18-8-19/h1-5,8,13H,7H2/b14-12+/t13-/m0/s1 Key:YTAOBBFIOAEMLL-REQDGWNSSA-N

Luliconazole (trade names Luzu, Lulicon) is an imidazole antifungal drug. As a 1% topical cream, It is indicated for the treatment of athlete's foot, jock itch, and ringworm caused by dermatophytes such as Trichophyton rubrum, Microsporum gypseum^[2] and Epidermophyton floccosum.^[1]

References

1 2 "LUZU (luliconazole) Cream, 1%. Full Prescribing Information." (PDF). Valeant Pharmaceuticals North America LLC. Retrieved 1 October 2015.
↑ "FDA approves luliconazole for tinea pedis". November 19, 2013. Retrieved 14 January 2014.

Wall/
membrane

Ergosterol
inhibitors

Imidazoles	Topical: bifonazole^‡ butoconazole chlormidazole^‡ clotrimazole^# croconazole^‡ eberconazole econazole fenticonazole^‡ flutrimazole isoconazole^‡ ketoconazole luliconazole miconazole^# neticonazole^‡ omoconazole^‡ oxiconazole sertaconazole sulconazole tioconazole Systemic: ketoconazole
Triazoles	Topical: efinaconazole fluconazole^# fosfluconazole terconazole Systemic: fluconazole^# hexaconazole^‡ isavuconazole itraconazole posaconazole voriconazole Unknown: albaconazole^‡ ravuconazole^†
Thiazoles	Topical: abafungin^‡

Allylamines	Topical: naftifine terbinafine Systemic: terbinafine
Benzylamines	Topical: butenafine

Others

Intracellular

Pyrimidine analogues/ thymidylate synthase inhibitors	flucytosine^#
Mitotic inhibitors	griseofulvin^#
Aminoacyl tRNA synthetase inhibitors	tavaborole

Others

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