List of unusual biological names
The trouble with unusual names have not been lost on scientists when needing to explain genetic diseases to lay-people.[1] This has particularly been noted in patients with a defect in the sonic hedgehog gene pathway and the disease formerly named CATCH22 for "cardiac anomaly, T-cell deficit, clefting and hypocalcaemia for chromosome 22q11.2 microdeletions". This name was abandoned due to the no-win connotations.[2] In 2005, Pokémon threatened to sue the discoverer of POKEMON because the name was attracting attention when its link to the development of cancer was published.[3] In 1993, a researcher at the University of Cambridge was ordered to change the name of the gene he had discovered, VELCRO, because of copyright issues.[3]
Techniques
- ChIA-PET: Chromatin Interaction Analysis by Paired-End Tag Sequencing
Genes and proteins
In the early discovery days of genomics, genes were often given creative names upon discovery. Although a nomenclature committee has now been formed, several of these names remain.[4]
| Name | Explanation | Biological role |
|---|---|---|
| Mothers against decapentaplegic 1-9, and the associated Daughters against dpp[5] | Takes the name from "Mothers against drunk driving" and similar campaigns | Mutations in the gene of the mother cause improper development in the offspring |
| SMURF1 and SMURF2, which interacts with Mothers against decapentaplegic 7 | SMAD Ubiquitination Regulatory Factor 1/2 | |
| POKEMON | POK erythroid myeloid ontogenic factor, changed to Zbtb7 after a lawsuit was threatened | |
| Pikachurin | ||
|
named for the video game character Sonic the Hedgehog | critical gene involved in development and tumorigenesis |
| Fizzy-related | ||
| Buttonhead | ||
| Headcase[6] | ||
| Hunchback | ||
| MAP kinase kinase kinase and MAP kinase kinase kinase kinase | ||
| Deadpan | ||
| Dreadlocks | mutations in this gene cause cell projections to clump together like dreadlocks | murine ortholog of Nck |
| Slit-Robo and the associated Netrin-Frazzled | ||
| Exuperantia | named after St. Exuperantia who was beheaded | a gene associated with dividing the head and body into regions |
| Bag-of-marbles | ||
| ELMO | Engulfment and Cell Motility | contains the family ELMO1, ELMO2, and ELMO3 |
| Indy | short for I'm not dead yet | |
| DIABLO | Direct IAP binding protein, low | |
| NEMO | NF-kappa-B essential modulator | |
| Dunce | a memory-related gene, with "dunce" referring to a dolt | a memory-related gene associated with Rutabaga |
| Methuselah-like proteins | named for Methuselah, extends the lifespan of an organism | |
| Salvador | ||
| Slingshot homolog | ||
| Tinman gene | named for the tinman, required for proper development of the heart | |
| Lunatic Fringe, Manic Fringe, and Radical Fringe | ||
| Ken and Barbie[7] | drosophila gene | |
| Cheap date[8] | mutations in this gene cause marked susceptibility to alcohol intoxication | |
| Swiss cheese[9] | mutations cause the brain to develop with lesions resembling swiss cheese | |
| SPOCK1 | Zebrafish with this mutation develop pointed-ears reminiscent of Spock | |
| Scramblase | an enzyme that "scrambles" phospholipids between the inside and outside of the cell membrane | |
| Flippase | a protein that "flips" phosphatidylserines on the inner side of the cell membrane | |
| Floppase | a protein that "flops" phosphatidylserines on the outer side of the cell membrane |
Molecules
- Moronic acid, a natural triterpene
- Traumatic acid, a monounsaturated dicarboxylic acid naturally occurring in plants
See also
References
- ↑ Hopkin, Michael (2006). "Troublesome gene names get the boot". News@nature. doi:10.1038/news061106-2.
- ↑ MacLean, Ken (2006). "Humour of gene names lost in translation to patients". Nature. 439 (7074): 266. Bibcode:2006Natur.439..266M. PMID 16421543. doi:10.1038/439266d.
- 1 2 Simonite, Tom (2005). "Pokémon blocks gene name". Nature. 438 (7070): 897. Bibcode:2005Natur.438..897S. PMID 16355177. doi:10.1038/438897a.
- ↑ https://psmag.com/sonic-hedgehog-dicer-and-the-problem-with-naming-genes-113c58df8f7a%5B%5D
- ↑ http://flybase.org/reports/FBgn0020493.html%5B%5D
- ↑ http://www.sdbonline.org/sites/fly/dbzhnsky/headcse1.htm%5B%5D
- ↑ Lukacsovich, Tamas; Yuge, Kazuya; Awano, Wakae; Asztalos, Zoltan; Kondo, Shunzo; Juni, Naoto; Yamamoto, Daisuke (2003). "Theken and barbie gene encoding a putative transcription factor with a BTB domain and three zinc finger motifs functions in terminalia development of Drosophila". Archives of Insect Biochemistry and Physiology. 54 (2): 77–94. PMID 14518006. doi:10.1002/arch.10105.
- ↑ Moore, Monica S; Dezazzo, Jim; Luk, Alvin Y; Tully, Tim; Singh, Carol M; Heberlein, Ulrike (1998). "Ethanol Intoxication in Drosophila: Genetic and Pharmacological Evidence for Regulation by the cAMP Signaling Pathway". Cell. 93 (6): 997–1007. PMID 9635429. doi:10.1016/S0092-8674(00)81205-2.
- ↑ Kretzschmar, D; Hasan, G; Sharma, S; Heisenberg, M; Benzer, S (1997). "The swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila". The Journal of Neuroscience. 17 (19): 7425–32. PMID 9295388.
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