List of adaptins

Clathrin adaptor proteins, also known as adaptins, are proteins that mediate the formation of vesicles for intracellular trafficking and secretion. Adaptins are clustered subunits of adaptor protein (AP) complexes..^[1] There are several types of adaptin, each related to a different AP complex.

Adaptins show sequence similarity to some COPI subunits, thus they are thought to have a common evolutionary origin.^[1] The adaptin is a heterotetramer consisting of two large adaptins (beta and one other depending on the complex), a medium adaptin (mu), and a small adaptin (sigma):

complex 1
- AP1B1
- AP1G1
- AP1G2
- AP1M1
- AP1M2
- AP1S1
- AP1S2
- AP1S3
complex 2
- AP2A1
- AP2A2
- AP2B1
- AP2M1
- AP2S1
complex 3
- AP3B1
- AP3B2
- AP3D1
- AP3M1
- AP3M2
- AP3S1
- AP3S2
complex 4
- AP4B1
- AP4E1
- AP4M1
- AP4S1
complex 5^[2]
- AP5Z1
- AP5B1
- AP5M1
- AP5S1

A diagram of the 5 complexes is shown here

References

1 2 Boehm, Markus; Bonifacino, Juan S. (October 2001). "Adaptins". Molecular Biology of the Cell. 12 (10): 2907–2920. ISSN 1059-1524.
↑ Mattera R, Guardia CM, Sidhu SS, Bonifacino JS, J Biol Chem. 2015 Dec 25;290(52):30736-49. "Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex.". ncbi.nlm.nih.gov. American Society for Biochemistry and Molecular Biology. Retrieved 17 April 2017.

Alberts, Johnson, Lewis, Raff, Roberts, Walter: Molecular Biology of the Cell, 4th edition (2002), Garland Science.
Hirst J, D. Barlow L, Francisco GC, Sahlender DA, Seaman MNJ, Dacks JB, et al. (2011) The Fifth Adaptor Protein Complex. PLoS Biol 9(10): e1001170. doi:10.1371/journal.pbio.1001170

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