Lipidome

The lipodome in connection with the total interactome of a cell.
The quantitative lipidome (on the level of lipid classes) of yeast Saccharomyces cerevisiae in different phases of growth.[1]

The lipidome refers to the totality of lipids in cells. Lipids are one of the four major molecular components of biological organisms, along with proteins, sugars and nucleic acids. Lipidome is a term coined in the context of omics in modern biology, within the field of lipidomics.[2] It can be studied using mass spectrometry and bioinformatics as well as traditional lab-based methods.[3][4] The lipidome of a cell can be subdivided into the membrane-lipidome and mediator-lipidome.[5]

The first cell lipidome to be published was that of a mouse macrophage in 2010.[6] The lipidome of the yeast Saccharomyces cerevisiae has been characterised with an estimated 95% coverage;[7] studies of the human lipidome are ongoing.[2][6] For example, the human plasma lipidome consist of almost 600 distinct molecular species.[8] Research suggests that the lipidome of an individual may be able to indicate cancer risks associated with dietary fats, particularly breast cancer.[9][10]

See also

References

  1. ↑ Klose, C; Surma, MA.; Gerl, MJ.; Meyenhofer, F; Shevchenko, A; Simons, K (April 2012). "Flexibility of a Eukaryotic Lipidome – Insights from Yeast Lipidomics". PLoS ONE. 7 (4): e35063. PMC 3329542 Freely accessible. PMID 22529973. doi:10.1371/journal.pone.0035063.
  2. 1 2 Quehenberger O, Armando AM, Brown AH, et al. (November 2010). "Lipidomics reveals a remarkable diversity of lipids in human plasma". J. Lipid Res. 51 (11): 3299–305. PMC 2952570 Freely accessible. PMID 20671299. doi:10.1194/jlr.M009449.
  3. ↑ Subramaniam S; Fahy E; Gupta S; Sud M; Byrnes R.W; Cotter D; Dinasarapu A.R; Maurya M.R (2011). "Bioinformatics and Systems Biology of the Lipidome". Chemical Reviews. 111 (10): 6452–6490. PMC 3383319 Freely accessible. PMID 21939287. doi:10.1021/cr200295k.
  4. ↑ Seppänen-Laakso T, Oresic M (March 2009). "How to study lipidomes". J. Mol. Endocrinol. 42 (3): 185–90. PMID 19060177. doi:10.1677/JME-08-0150.
  5. ↑ "Lipidomics". BioSoft. Retrieved 7 May 2011.
  6. 1 2 "First Functioning 'Lipidome' of Mouse Macrophage Described". ScienceDaily. Retrieved 7 May 2011.
  7. ↑ Ejsing CS, Sampaio JL, Surendranath V, et al. (February 2009). "Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry". Proc. Natl. Acad. Sci. U.S.A. 106 (7): 2136–41. PMC 2650121 Freely accessible. PMID 19174513. doi:10.1073/pnas.0811700106.
  8. ↑ Quehenberger, Oswald; Dennis, Edward A. (2011-11-10). "The human plasma lipidome". The New England Journal of Medicine. 365 (19): 1812–1823. ISSN 1533-4406. PMC 3412394 Freely accessible. PMID 22070478. doi:10.1056/NEJMra1104901.
  9. ↑ Bougnoux P, Hajjaji N, Couet C (2008). "The lipidome as a composite biomarker of the modifiable part of the risk of breast cancer". Prostaglandins Leukot. Essent. Fatty Acids. 79 (3–5): 93–6. PMID 18930643. doi:10.1016/j.plefa.2008.09.004.
  10. ↑ Bougnoux P, Giraudeau B, Couet C (March 2006). "Diet, cancer, and the lipidome". Cancer Epidemiol. Biomarkers Prev. 15 (3): 416–21. PMC 2755770 Freely accessible. PMID 16537692. doi:10.1158/1055-9965.EPI-05-0546.

Further reading

  • Mutch DM, Fauconnot L, Grigorov M, Fay LB (2006). "Putting the 'Ome' in lipid metabolism". Biotechnol Annu Rev. 12: 67–84. PMID 17045192. doi:10.1016/S1387-2656(06)12003-7. 
  • van der Meer-Janssen YP, van Galen J, Batenburg JJ, Helms JB (January 2010). "Lipids in host-pathogen interactions: pathogens exploit the complexity of the host cell lipidome". Prog. Lipid Res. 49 (1): 1–26. PMID 19638285. doi:10.1016/j.plipres.2009.07.003. 
  • Gaspar ML, Aregullin MA, Jesch SA, Nunez LR, Villa-García M, Henry SA (March 2007). "The emergence of yeast lipidomics". Biochim. Biophys. Acta. 1771 (3): 241–54. PMID 16920401. doi:10.1016/j.bbalip.2006.06.011. 


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