Limulus clotting enzyme
| Limulus clotting enzyme | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.21.86 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Limulus clotting enzyme (EC 3.4.21.86, clotting enzyme) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction
- Selective cleavage of -Arg18- and -Arg47- bonds in coagulogen to form coagulin and fragments
This enzyme is present in the hemocyte granules of horseshoe crabs Limulus and Tachypleus.
References
- ↑ Muta, T.; Hashimoto, R.; Miyata, T.; Nishimura, H.; Toh, Y.; Iwanaga, S. (1990). "Proclotting enzyme from horseshoe crab hemocytes. cDNA cloning, disulfide locations, and subcellular localization". J. Biol. Chem. 265: 22426–22433. PMID 2266134.
- ↑ Tokunaga, F.; Nakajima, H.; Iwanaga, S. (1991). "Further studies on lipopolysaccharide-sensitive serine protease zymogen (factor C): its isolation from Limulus polyphemus hemocytes and identification as an intracellular zymogen activated by α-chymotrypsin, not by trypsin". J. Biochem. (Tokyo). 109: 150–157. PMID 2016264.
External links
- Limulus clotting enzyme at the US National Library of Medicine Medical Subject Headings (MeSH)
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