Leukotriene receptor
The leukotriene (LT) receptors are G protein-coupled receptors that bind and are activated by the leukotrienes. They include the following proteins:
- Leukotriene B4 receptors (BLTRs) - bind to and are activated by LTB4:
- BLT1 (Leukotriene B4 receptor 1) - LTB4R
- BLT2 (Leukotriene B4 receptor 2) - LTB4R2
- Cysteinyl leukotriene receptors (CysLTRs) - bind to and are activated by LTC4, LTD4, and LTE4:
- CysLT1 (Cysteinyl leukotriene receptor 1) - CYSLTR1
- CysLT2 (Cysteinyl leukotriene receptor 2) - CYSLTR2
The recently elucidated CysLTE, represented by GPR99/OXGR1, may constitute a third CysLTR.[1]
See also
References
- ↑ Kanaoka Y, Maekawa A, Austen KF (2013). "Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand". J. Biol. Chem. 288 (16): 10967–72. PMC 3630866
. PMID 23504326. doi:10.1074/jbc.C113.453704.
External links
- IUPHAR GPCR Database - Leukotriene receptors
- Leukotriene Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
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