Leukotriene-C4 hydrolase

Leukotriene-C4 hydrolase
Identifiers
EC number 3.4.19.14
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Leukotriene-C4 hydrolase (EC 3.4.19.14, gamma-glutamyl leukotrienase, GGT5) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction

leukotriene C4 + H2O leukotriene D4 + L-glutamate

The mouse enzyme is specific for leukotriene C4.

References

  1. ↑ Carter, B.Z.; Wiseman, A.L.; Orkiszewski, R.; Ballard, K.D.; Ou, C.N.; Lieberman, M.W. (1997). "Metabolism of leukotriene C4 in γ-glutamyl transpeptidase-deficient mice". J. Biol. Chem. 272: 12305–12310. PMID 9139674. doi:10.1074/jbc.272.19.12305.
  2. ↑ Shi, Z.Z.; Han, B.; Habib, G.M.; Matzuk, M.M.; Lieberman, M.W. (2001). "Disruption of γ-glutamyl leukotrienase results in disruption of leukotriene D4 synthesis in vivo and attenuation of the acute inflammatory response". Mol. Cell. Biol. 21: 5389–5395. PMC 87261 Freely accessible. PMID 11463821. doi:10.1128/mcb.21.16.5389-5395.2001.
  3. ↑ Han, B.; Luo, G.; Shi, Z.Z.; Barrios, R.; Atwood, D.; Liu, W.; Habib, G.M.; Sifers, R.N.; Corry, D.B.; Lieberman, M.W. (2002). "γ-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D4 formation in vivo". Am J Pathol. 161: 481–490. PMC 1850737 Freely accessible. PMID 12163373. doi:10.1016/s0002-9440(10)64204-6.
  4. ↑ Wickham, S.; West, M.B.; Cook, P.F.; Hanigan, M.H. (2011). "Gamma-glutamyl compounds: substrate specificity of γ-glutamyl transpeptidase enzymes". Anal. Biochem. 414: 208–214. PMC 3099546 Freely accessible. PMID 21447318. doi:10.1016/j.ab.2011.03.026.
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