Lactate permease family
| Lactate permease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | LctP | ||||||||
| Pfam | PF02652 | ||||||||
| InterPro | IPR003804 | ||||||||
| TCDB | 2.A.14 | ||||||||
| |||||||||
The lactate permease (LctP) family (TC# 2.A.14) is a family of transport proteins belonging to the ion transporter (IT) superfamily.[1]
Function
Characterized members of this family possess 15-18 transmembrane segments (TMSs) and are roughly 460-565 amino acyl residues in length.
General transport reaction
Transport reactions catalyzed by functionally characterized members of the LctP family include:[2]
D- or L-lactate or glycolate (out) + H+ (out) → D- or L-lactate or glycolate (in) + H+ (in).
References
- ↑ Prakash, Shraddha; Cooper, Garret; Singhi, Soumya; Saier, Milton H. (2003-12-03). "The ion transporter superfamily". Biochimica et Biophysica Acta. 1618 (1): 79–92. ISSN 0006-3002. PMID 14643936. doi:10.1016/j.bbamem.2003.10.010.
- ↑ "2.A.14 The Lactate Permease (LctP) Family". Transporter Classification Database. Retrieved 2016-03-02.
Further reading
- Moraes, Trevor F.; Reithmeier, Reinhart A. F. (2012-11-01). "Membrane transport metabolons".Biochimica et Biophysica Acta 1818 (11): 2687–2706. doi:10.1016/j.bbamem.2012.06.007. ISSN 0006-3002. PMID 227052603.
- Núñez, María Felisa; Kwon, Ohsuk; Wilson, T. Hastings; Aguilar, Juan; Baldoma, Laura; Lin, Edmund C. C. (2002-01-18). "Transport of L-Lactate, D-Lactate, and glycolate by the LldP and GlcA membrane carriers of Escherichia coli". Biochemical and Biophysical Research Communications 290 (2): 824–829. doi:10.1006/bbrc.2001.6255. ISSN 0006-291X. PMID 11785976.
- Rabus, R.; Jack, D. L.; Kelly, D. J.; Saier, M. H. (1999-12-01). "TRAP transporters: an ancient family of extracytoplasmic solute-receptor-dependent secondary active transporters". Microbiology (Reading, England). 145 ( Pt 12): 3431–3445. doi:10.1099/00221287-145-12-3431. ISSN 1350-0872. PMID 10627041.
- Saier, M. H.; Eng, B. H.; Fard, S.; Garg, J.; Haggerty, D. A.; Hutchinson, W. J.; Jack, D. L.; Lai, E. C.; Liu, H. J. (1999-02-25). "Phylogenetic characterization of novel transport protein families revealed by genome analyses". Biochimica et Biophysica Acta 1422 (1): 1–56. ISSN 0006-3002. PMID 10082980.
As of 12 March 2016, this article is derived in whole or in part from Transporter Classification Database. The copyright holder has licensed the content in a manner that permits reuse under CC BY-SA 3.0 and GFDL. All relevant terms must be followed. The original text was at "2.A.14 The Lactate Permease (LctP) Family".
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