Laboratoires Pierre Fabre

Pierre Fabre S.A.
Private limited company
Industry Pharmaceutical
Founded 1951 (1951)
Headquarters Paris, France[1]
Area served
 Worldwide
Key people
  • Bertrand Parmentier
  • (President and CEO)
Number of employees
 13,000 (2015) (Homepage)
Website www.pierre-fabre.com

Laboratoires Pierre Fabre is a French multinational pharmaceutical and cosmetics company. The company had a consolidated turnover of 1.978 billion euros in 2012 (including 54% international).[2] It is headquartered in the city of Castres, Midi-Pyrénées, France.[2]

Founded in 1962 by Pierre Fabre (1926-2013),[2] the company is present in over 130 countries. Laboratories Pierre Fabre had approximately 10,000 employees in 2012, 33% of whom are internationally based, while the remaining 6,700 employees were based in France.[2] The company's business activity is focused on research, development, manufacturing and marketing of cosmetics, prescription medicines and family health products. Pharmaceuticals and phytotherapy represent 47% of turnover, whereas cosmetics represent 53% (percentages of 2012 turnover).

Pierre Fabre is best known for its vinorelbine (Navelbine),[3][4] an anticancer drug[5] of the vinca alkaloid class.[6][7][8] They also developed vinflunine,[9] a fluorinated vinca alkaloid derivative[10][11] available in Australia for "advanced or metastatic transitional cell carcinoma of the urothelial tract after failure of a prior platinum containing regimen."[12]

Olivier Bohuon, now Chief Executive of Smith & Nephew, was Chief Executive from September 2010 to April 2011.

The Pierre Fabre Foundation

The Pierre Fabre Foundation was recognized as a public utility in 1999 and its mission is to help third-world countries to obtain quality drugs, ensure better quality control of drugs, use local therapeutic resources and train scientists for the inspection of drugs.

References

  1. ↑ "Company Overview of Pierre Fabre S.A.". Retrieved December 9, 2014.
  2. 1 2 3 4 "Pierre Fabre, founder of pharmaceutical giant, dies". Agence France Presse. France 24. 2013-07-20. Archived from the original on 2013-07-23. Retrieved 2013-08-17.
  3. ↑ Ngo, Quoc Anh; Roussi, Fanny; Cormier, Anthony; Thoret, Sylviane; Knossow, Marcel; Guénard, Daniel; Guéritte, Françoise (2009). "Synthesis and biological evaluation of Vinca alkaloids and phomopsin hybrids". Journal of Medicinal Chemistry. 52 (1): 134–142. PMID 19072542. doi:10.1021/jm801064y.
  4. ↑ Keglevich, Péter; Hazai, Laszlo; Kalaus, György; Szántay, Csaba (2012). "Modifications on the basic skeletons of vinblastine and vincristine". Molecules. 17: 5893–5914. PMID 22609781. doi:10.3390/molecules17055893.
  5. ↑ Faller, Bryan A.; Pandi, Trailokya N. (2011). "Safety and efficacy of vinorelbine in the treatment of non-small cell lung cancer". Clinical Medicine Insights: Oncology. 5: 131–144. PMC 3117629 Freely accessible. doi:10.4137/CMO.S5074.
  6. ↑ van der Heijden, Robert; Jacobs, Denise I.;  Snoeijer, Wim;  Hallard, Didier;  Verpoorte, Robert (2004). "The Catharanthus alkaloids: Pharmacognosy and biotechnology". Current Medicinal Chemistry. 11 (5): 607–628. PMID 15032608. doi:10.2174/0929867043455846.
  7. ↑ Raviña, Enrique (2011). "Vinca alkaloids". The evolution of drug discovery: From traditional medicines to modern drugs. John Wiley & Sons. pp. 157–159. ISBN 9783527326693.
  8. ↑ Cooper, Raymond; Deakin, Jeffrey John (2016). "Africa's gift to the world". Botanical Miracles: Chemistry of Plants That Changed the World. CRC Press. pp. 46–51. ISBN 9781498704304.
  9. ↑ "Bristol-Myers Squibb and Pierre Fabre Provide Update On Vinflunine Development Status" (Press release). Bristol-Myers Squibb. November 23, 2007. Archived from the original on May 28, 2008. Retrieved June 27, 2008.
  10. ↑ Fahy, Jacques; Duflos, Alain; Ribet, Jean-Paul; Jacquesy, Jean-Claude; Berrier, Christian; Jouannetaud, Marie-Paule; Zunino, Fabien (1997). "Vinca Alkaloids in Superacidic Media: A Method for Creating a New Family of Antitumor Derivatives". J. Am. Chem. Soc. 119 (36): 8576–8577. doi:10.1021/ja971864w.
  11. ↑ Kruczynski, Anna; Barret, Jean-Marc; Etiévant, Chantal; Colpaert, Francis; Fahy, Jacques; Hill, Bridget T. (1998). "Antimitotic and tubulin-interacting properties of vinflunine, a novel fluorinated Vinca alkaloid". Biochem. Pharmacol. 55 (5): 635–648. PMID 9515574. doi:10.1016/S0006-2952(97)00505-4.
  12. ↑ "Vinflunine, solution concentration for I.V. infusion, 50 mg in 2 mL and 250 mg in 10 mL (as ditartrate), Javlor® – November 2011". Pharmaceutical Benefits Scheme. March 16, 2012. Retrieved June 22, 2017.


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