LMLN
LMLN | |||||||||||||||||
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Identifiers | |||||||||||||||||
Aliases | LMLN, GP63, INV, IX14, MSP, leishmanolysin like peptidase | ||||||||||||||||
External IDs | MGI: 2444736 HomoloGene: 13198 GeneCards: LMLN | ||||||||||||||||
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Orthologs | |||||||||||||||||
Species | Human | Mouse | |||||||||||||||
Entrez | |||||||||||||||||
Ensembl | |||||||||||||||||
UniProt | |||||||||||||||||
RefSeq (mRNA) | |||||||||||||||||
RefSeq (protein) | |||||||||||||||||
Location (UCSC) | Chr 3: 197.96 – 198.04 Mb | Chr 16: 33.06 – 33.13 Mb | |||||||||||||||
PubMed search | [1] | [2] | |||||||||||||||
Wikidata | |||||||||||||||||
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Leishmanolysin-like (metallopeptidase M8 family) is a protein that in humans is encoded by the LMLN gene. [3]
Function
This gene encodes a zinc-metallopeptidase. The encoded protein may play a role in cell migration and invasion. Studies of a similar protein in Drosophila indicate a potential role in mitotic progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009].
References
Further reading
- Cobbe, N; Marshall, K. M.; Gururaja Rao, S; Chang, C. W.; Di Cara, F; Duca, E; Vass, S; Kassan, A; Heck, M. M. (2009). "The conserved metalloprotease invadolysin localizes to the surface of lipid droplets". Journal of Cell Science. 122 (Pt 18): 3414–23. PMC 2736869 . PMID 19706689. doi:10.1242/jcs.044610.
- McHugh, B; Krause, S. A.; Yu, B; Deans, A. M.; Heasman, S; McLaughlin, P; Heck, M. M. (2004). "Invadolysin: A novel, conserved metalloprotease links mitotic structural rearrangements with cell migration". The Journal of Cell Biology. 167 (4): 673–86. PMC 2172566 . PMID 15557119. doi:10.1083/jcb.200405155.
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