LJ-001

LJ-001
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
Formula C17H13NO2S2
Molar mass 327.420
3D model (JSmol)

LJ-001 is a broad-spectrum antiviral drug developed as a potential treatment for enveloped viruses. It acts as an inhibitor which blocks viral entry into host cells at a step after virus binding but before virus–cell fusion, and also irreversibly inactivates the virions themselves by generating reactive singlet oxygen molecules which damage the viral membrane. In cell culture tests in vitro, LJ-001 was able to block and disable a wide range of different viruses, including influenza A, filoviruses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses, flaviviruses, and HIV.[1] Unfortunately LJ-001 itself was unsuitable for further development, as it has poor physiological stability and requires light for its antiviral mechanism to operate.[2] However the discovery of this novel mechanism for blocking virus entry and disabling the virion particles has led to LJ-001 being used as a lead compound to develop a novel family of more effective antiviral drugs with improved properties.[3][4]

See also

References

  1. ↑ Wolf, M. C.; Freiberg, A. N.; Zhang, T.; Akyol-Ataman, Z.; Grock, A.; Hong, P. W.; Li, J.; Watson, N. F.; Fang, A. Q.; Aguilar, H. C.; Porotto, M.; Honko, A. N.; Damoiseaux, R.; Miller, J. P.; Woodson, S. E.; Chantasirivisal, S.; Fontanes, V.; Negrete, O. A.; Krogstad, P.; Dasgupta, A.; Moscona, A.; Hensley, L. E.; Whelan, S. P.; Faull, K. F.; Holbrook, M. R.; Jung, M. E.; Lee, B. (2010). "A broad-spectrum antiviral targeting entry of enveloped viruses". Proceedings of the National Academy of Sciences. 107 (7): 3157. doi:10.1073/pnas.0909587107.
  2. ↑ The Rise and Fall of LJ-001. Memoirs of a Defective Brain, 19 August 2013
  3. ↑ Vigant, F.; Lee, J.; Hollmann, A.; Tanner, L. B.; Akyol Ataman, Z.; Yun, T.; Shui, G.; Aguilar, H. C.; Zhang, D.; Meriwether, D.; Roman-Sosa, G.; Robinson, L. R.; Juelich, T. L.; Buczkowski, H.; Chou, S.; Castanho, M. A. R. B.; Wolf, M. C.; Smith, J. K.; Banyard, A.; Kielian, M.; Reddy, S.; Wenk, M. R.; Selke, M.; Santos, N. C.; Freiberg, A. N.; Jung, M. E.; Lee, B. (2013). "A Mechanistic Paradigm for Broad-Spectrum Antivirals that Target Virus-Cell Fusion". PLoS Pathogens. 9 (4): e1003297. PMC 3630091 Freely accessible. PMID 23637597. doi:10.1371/journal.ppat.1003297.
  4. ↑ Hollmann, A.; Castanho, M. A. R. B.; Lee, B.; Santos, N. C. (2014). "Singlet oxygen effects on lipid membranes: Implications for the mechanism of action of broad-spectrum viral fusion inhibitors". Biochemical Journal. 459: 161. PMID 24456301. doi:10.1042/BJ20131058.


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