LIMD1

Identifiers

LIMD1, LIM domains containing 1

External IDs

MGI: 1352502 HomoloGene: 8478 GeneCards: LIMD1

Gene ontology
Molecular function	• metal ion binding • protein binding • transcription corepressor activity • zinc ion binding
Cellular component	• cytoplasm • RISC complex • focal adhesion • adherens junction • P-body • cell junction • nucleus • transcription factor complex • cytosol • plasma membrane • cell-cell junction
Biological process	• response to hypoxia • regulation of transcription, DNA-templated • phosphorylation • negative regulation of osteoblast differentiation • transcription, DNA-templated • positive regulation of gene silencing by miRNA • multicellular organism development • negative regulation of hippo signaling • gene silencing by miRNA • cytoskeleton organization • cytoplasmic mRNA processing body assembly • regulation of cell shape • osteoblast development • gene silencing by RNA • negative regulation of transcription, DNA-templated • cell migration • negative regulation of canonical Wnt signaling pathway • signal transduction • regulation of transcription from RNA polymerase II promoter in response to hypoxia
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


8994


29806

Ensembl


ENSG00000144791


ENSMUSG00000025239

UniProt


Q9UGP4


Q9QXD8

RefSeq (mRNA)


NM_014240


NM_013860

RefSeq (protein)


NP_055055


NP_038888

Location (UCSC)

Chr 3: 45.56 – 45.69 Mb

Chr 9: 123.48 – 123.52 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

LIM domain-containing protein 1 is a protein that in humans is encoded by the LIMD1 gene.^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Kiss H, Kedra D, Yang Y, Kost-Alimova M, Kiss C, O'Brien KP, Fransson I, Klein G, Imreh S, Dumanski JP (Feb 2000). "A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3". Hum Genet. 105 (6): 552–9. PMID 10647888. doi:10.1007/s004390051144.
↑ "Entrez Gene: LIMD1 LIM domains containing 1".

Jiang T, Altman S (2001). "Protein-protein interactions with subunits of human nuclear RNase P.". Proc. Natl. Acad. Sci. U.S.A. 98 (3): 920–5. PMC 14685 . PMID 11158571. doi:10.1073/pnas.021561498.
Kiss H, Kedra D, Kiss C, et al. (2001). "The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3.". Genomics. 73 (1): 10–9. PMID 11352561. doi:10.1006/geno.2000.6498.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763–72. PMID 15144186. doi:10.1021/ac035352d.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. PMC 442148 . PMID 15231748. doi:10.1101/gr.2334104.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Sharp TV, Munoz F, Bourboulia D, et al. (2004). "LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription.". Proc. Natl. Acad. Sci. U.S.A. 101 (47): 16531–6. PMC 534532 . PMID 15542589. doi:10.1073/pnas.0407123101.
Feng Y, Longmore GD (2005). "The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex.". Mol. Cell. Biol. 25 (10): 4010–22. PMC 1087715 . PMID 15870274. doi:10.1128/MCB.25.10.4010-4022.2005.
Huggins CJ, Gill M, Andrulis IL (2007). "Identification of rare variants in the hLIMD1 gene in breast cancer.". Cancer Genet. Cytogenet. 178 (1): 36–41. PMID 17889706. doi:10.1016/j.cancergencyto.2007.06.007.

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LIMD1

References

Further reading