Lymphocyte function-associated antigen 1
Lymphocyte function-associated antigen 1 (LFA-1) is found on all T-cells and also on B-cells, macrophages, neutrophils and NK cells and is involved in recruitment to the site of infection. It binds to ICAM-1 on antigen-presenting cells and functions as an adhesion molecule. LFA-1 is the first to bind T-cells to antigen-presenting cells and initially binds weakly. A signal from the T-cell receptor and/or the cytokine receptor changes the conformation and prolongs the cell contact, allowing the T-cell to proliferate. LFA-1/ICAM-1 interaction has recently been shown to be important for T cell-T cell interactions, leading to further T cell differentiation.
LFA-1 is part of the family of leukocyte integrins that are recognised by their common β-chains (β2, CD18). LFA-1 also has a distinct α-chain (αL, CD11a).
LFA-1 has also been found in a soluble form.[1]
See also
- Leukocyte adhesion deficiency
- Lifitegrast, a drug that blocks LFA-1 from binding to ICAM-1
Further reading
- Janeway, Travers, Walport, Shlomchik, Immunobiology 6th ed. (2005) Garland Science:NY
- Parham, Peter, The Immune System 3rd ed. (2009) Garland Science: London and New York
References
- ↑ Gjelstrup, L. C.; Boesen, T.; Kragstrup, T. W.; Jorgensen, A.; Klein, N. J.; Thiel, S.; Deleuran, B. W.; Vorup-Jensen, T. (8 September 2010). "Shedding of Large Functionally Active CD11/CD18 Integrin Complexes from Leukocyte Membranes during Synovial Inflammation Distinguishes Three Types of Arthritis through Differential Epitope Exposure". The Journal of Immunology. 185 (7): 4154–4168. doi:10.4049/jimmunol.1000952.
External links
- LFA-1 at the US National Library of Medicine Medical Subject Headings (MeSH)
- Davignon D, Martz E, Reynolds T, Kürzinger K, Springer TA (1981). "Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte-mediated killing". Proc. Natl. Acad. Sci. U.S.A. 78 (7): 4535–9. PMC 319826
. PMID 7027264. doi:10.1073/pnas.78.7.4535. - ITGAL ITGB2 Info with links in the Cell Migration Gateway
- Audrey Gérard; Omar Khan; Peter Beemiller; Erin Oswald; Joyce Hu; Mehrdad Matloubian; Matthew F Krummel (2013). "Secondary T cell–T cell synaptic interactions drive the differentiation of protective CD8+ T cells". Nature Immunology. 14: 356–363. PMC 3962671 . PMID 23475183. doi:10.1038/ni.2547.