LBX1

LBX1
Identifiers
Aliases	LBX1, HPX-6, HPX6, LBX1H, homeobox, ladybird homeobox 1
External IDs	MGI: 104867 HomoloGene: 4784 GeneCards: LBX1
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • sequence-specific DNA binding • DNA binding Cellular component • nucleus • transcription factor complex Biological process • multicellular organism development • heart looping • anatomical structure morphogenesis • cell differentiation • muscle organ development • neuron fate commitment • spinal cord motor neuron differentiation • regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification • regulation of transcription, DNA-templated • negative regulation of neuron differentiation • neuron fate determination • transcription, DNA-templated • nervous system development • negative regulation of cell proliferation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10660	16814
Ensembl	ENSG00000138136	ENSMUSG00000025216
UniProt	P52954	P52955
RefSeq (mRNA)	NM_006562	NM_010691
RefSeq (protein)	NP_006553	NP_034821
Location (UCSC)	Chr 10: 101.23 – 101.23 Mb	Chr 19: 45.23 – 45.24 Mb
PubMed search	[1]	[2]
Wikidata
View/Edit Human View/Edit Mouse

Transcription factor LBX1 is a protein that in humans is encoded by the LBX1 gene.^[3][4]

This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles.^[4]

References

Further reading