Karyorrhexis

Morphological characteristics of pyknosis and other forms of nuclear destruction

Karyorrhexis (from Greek κάρυον karyon, "kernel, seed or nucleus", and ῥῆξις rhexis, "bursting") is the destructive fragmentation of the nucleus of a dying cell^[1] whereby its chromatin is distributed irregularly throughout the cytoplasm. It is usually preceded by pyknosis and can occur as a result of either programmed cell death (apoptosis), senescence, or necrosis.

In apoptosis, the cleavage of DNA is done by Ca²⁺ and Mg²⁺ -dependent endonucleases.

References

↑ Zamzami N, Kroemer G (1999). "Apoptosis: Condensed matter in cell death". Nature. 401 (127): 127–8. PMID 10490018. doi:10.1038/43591.

Pathology
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Karyorrhexis

See also

References