Keratin 34
| KRT34 | |||||||||||||||||
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| Identifiers | |||||||||||||||||
| Aliases | KRT34, HA4, Ha-4, KRTHA4, hHa4, Keratin 34 | ||||||||||||||||
| External IDs | MGI: 1309994 HomoloGene: 31083 GeneCards: KRT34 | ||||||||||||||||
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| RNA expression pattern | |||||||||||||||||
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| More reference expression data | |||||||||||||||||
| Orthologs | |||||||||||||||||
| Species | Human | Mouse | |||||||||||||||
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| UniProt | |||||||||||||||||
| RefSeq (mRNA) | |||||||||||||||||
| RefSeq (protein) | |||||||||||||||||
| Location (UCSC) | Chr 17: 41.38 – 41.38 Mb | Chr 11: 100.04 – 100.04 Mb | |||||||||||||||
| PubMed search | [1] | [2] | |||||||||||||||
| Wikidata | |||||||||||||||||
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Keratin, type I cuticular Ha4 is a protein that in humans is encoded by the KRT34 gene.[3][4][5][6]
The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription.[6]
See also
- 34βE12 (keratin 903)
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Heid HW, Werner E, Franke WW (Feb 1987). "The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins". Differentiation. 32 (2): 101–19. PMID 2431943. doi:10.1111/j.1432-0436.1986.tb00562.x.
- ↑ Rogers MA, Winter H, Wolf C, Heck M, Schweizer J (Nov 1998). "Characterization of a 190-kilobase pair domain of human type I hair keratin genes". J Biol Chem. 273 (41): 26683–91. PMID 9756910. doi:10.1074/jbc.273.41.26683.
- ↑ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. PMC 2064177
. PMID 16831889. doi:10.1083/jcb.200603161. - 1 2 "Entrez Gene: KRT34 keratin 34".
Further reading
- Yu J, Yu DW, Checkla DM, et al. (1993). "Human hair keratins.". J. Invest. Dermatol. 101 (1 Suppl): 56S–59S. PMID 7686952. doi:10.1111/1523-1747.ep12362635.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. PMC 1847948 . PMID 17353931. doi:10.1038/msb4100134.
- Raica M, Zylis D, Cîmpean AM (2007). "Cytokeratin 20, 34betaE12 and overexpression of HER-2/neu in urine cytology as predictors of recurrences in superficial urothelial carcinoma.". Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. 46 (1): 11–5. PMID 16286979.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Langbein L, Rogers MA, Winter H, et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle.". J. Biol. Chem. 274 (28): 19874–84. PMID 10391933. doi:10.1074/jbc.274.28.19874.
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