Kelch-like protein 1

KLHL1

Identifiers

KLHL1, MRP2, kelch like family member 1

External IDs

MGI: 2136335 HomoloGene: 56903 GeneCards: KLHL1

Gene ontology
Molecular function	• ubiquitin-protein transferase activity • actin binding
Cellular component	• Cul3-RING ubiquitin ligase complex • cytoskeleton • dendrite • neuronal cell body • cytoplasm
Biological process	• cerebellar Purkinje cell layer development • actin cytoskeleton organization • locomotory behavior • adult walking behavior • dendrite development • protein ubiquitination
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


57626


93688


ENSG00000150361


ENSMUSG00000022076


Q9NR64


Q9JI74

RefSeq (mRNA)


NM_020866 NM_001286725


NM_053105

RefSeq (protein)


NP_001273654 NP_065917


NP_444335

Location (UCSC)

Chr 13: 69.7 – 70.11 Mb

Chr 14: 96.11 – 96.52 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Kelch-like protein 1 is a protein that in humans is encoded by the KLHL1 gene.^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Nemes JP, Benzow KA, Moseley ML, Ranum LP, Koob MD (Sep 2000). "The SCA8 transcript is an antisense RNA to a brain-specific transcript encoding a novel actin-binding protein (KLHL1)". Hum Mol Genet. 9 (10): 1543–51. PMID 10888605. doi:10.1093/hmg/9.10.1543.
↑ "Entrez Gene: KLHL1 kelch-like 1 (Drosophila)".

Further reading

Aromolaran KA, Benzow KA, Koob MD, Piedras-Rentería ES (2007). "The Kelch-like protein 1 modulates P/Q-type calcium current density.". Neuroscience. 145 (3): 841–50. PMID 17289272. doi:10.1016/j.neuroscience.2006.12.046.
Seng S, Avraham HK, Jiang S, et al. (2007). "KLHL1/MRP2 mediates neurite outgrowth in a glycogen synthase kinase 3beta-dependent manner.". Mol. Cell. Biol. 26 (22): 8371–84. PMC 1636797 . PMID 16982692. doi:10.1128/MCB.02167-05.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science. 307 (5715): 1621–5. PMID 15761153. doi:10.1126/science.1105776.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature. 428 (6982): 522–8. PMC 2665288 . PMID 15057823. doi:10.1038/nature02379.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (2): 143–50. PMID 10819331. doi:10.1093/dnares/7.2.143.

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