KLF11

KLF11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1PO4
Identifiers
Aliases	KLF11, FKLF, FKLF1, MODY7, TIEG2, Tieg3, Kruppel-like factor 11, Kruppel like factor 11
External IDs	MGI: 2653368 HomoloGene: 2668 GeneCards: KLF11
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • transcription regulatory region DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • DNA binding • protein binding • metal ion binding • nucleic acid binding Cellular component • nucleus • nucleoplasm • cytosol • focal adhesion • nuclear body Biological process • positive regulation of apoptotic process • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • regulation of transcription involved in G1/S transition of mitotic cell cycle • transcription, DNA-templated • negative regulation of cell proliferation • apoptotic process • cellular response to peptide Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8462	194655
Ensembl	ENSG00000172059	ENSMUSG00000020653
UniProt	O14901	Q8K1S5
RefSeq (mRNA)	NM_001177716 NM_001177718 NM_003597	NM_178357
RefSeq (protein)	NP_001171187 NP_001171189 NP_003588	NP_848134
Location (UCSC)	Chr 2: 10.04 – 10.05 Mb	Chr 12: 24.65 – 24.66 Mb
PubMed search	[1]	[2]
Wikidata
View/Edit Human View/Edit Mouse

Krueppel-like factor 11 is a protein that in humans is encoded by the KLF11 gene.^[3][4][5]

KLF11 is a mesoderm derived, zinc finger transcription factor in the Krüppel-like factor (KLF) family. It binds to SP1- like GC- rich sequences in epsilon and gamma globin gene promoters inhibiting cellular growth and causing apoptosis. In the regulation of genes, it is involved in cellular inflammation and differentiation, making it an essential factor in early embryonic development This gene binds to promoters of genes involved in cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism, specifically pancreatic beta cell function. Defects in KLF11 affect glucose metabolism, insulin transcription, insulin processing, and insulin secretion which cause type 2 diabetes in adults and maturity-onset diabetes of the young type 7. These types of diabetes are caused by KLF11 interacting with co-repressors in the pancreatic islet beta cells. KLF11 has recently been studied to be involved in endometriosis since it regulated the expression of extracellular matrix genes. Its absence in extracellular matrix genes created a more fibrogenic response by the tissue. This was proved by creating a “knockout” model. The experiment showed that the absence of KLF11 showed higher amounts of fibrosis indicating that it prevents the growth of endometriotic lesions and inhibits pathological scarring.

^[6][7][8]

Interactions

KLF11 has been shown to interact with SIN3A.^[9][10]

See also

• Kruppel-like factors
• Maturity onset diabetes of the young

References

Further reading

External links

• KLF11 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.