KIAA1967

CCAR2

Identifiers

CCAR2, DBC-1, DBC1, KIAA1967, NET35, p30 DBC, p30DBC, cell cycle and apoptosis regulator 2

External IDs

MGI: 2444228 HomoloGene: 10910 GeneCards: CCAR2

Gene ontology
Molecular function	• RNA polymerase II core binding • enzyme inhibitor activity • protein binding • enzyme binding • RNA binding
Cellular component	• cytoplasm • nucleoplasm • DBIRD complex • mitochondrial matrix • nuclear chromatin • spliceosomal complex • nucleus
Biological process	• mitochondrial fragmentation involved in apoptotic process • negative regulation of catalytic activity • regulation of transcription, DNA-templated • regulation of protein stability • positive regulation of DNA damage checkpoint • rhythmic process • positive regulation of canonical Wnt signaling pathway • mRNA processing • regulation of DNA-templated transcription, elongation • regulation of protein deacetylation • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage • Wnt signaling pathway • transcription, DNA-templated • cellular response to DNA damage stimulus • regulation of circadian rhythm • negative regulation of cell growth • RNA splicing • negative regulation of proteasomal ubiquitin-dependent protein catabolic process • positive regulation of apoptotic process • regulation of cellular response to heat • cell cycle • negative regulation of transcription, DNA-templated • response to UV • apoptotic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


57805


219158

Ensembl


ENSG00000158941


ENSMUSG00000033712

UniProt


Q8N163


Q8VDP4

RefSeq (mRNA)


NM_021174 NM_199205


NM_146055

RefSeq (protein)


NP_066997


NP_666167

Location (UCSC)

Chr 8: 22.6 – 22.62 Mb

Chr 14: 70.14 – 70.15 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

KIAA1967, also known as Deleted in Breast Cancer 1, is a protein which in humans is encoded by the KIAA1967 gene.^[3]^[4]^[5]

Function

Recent studies show that DBC1 is an inhibitor of the sirtuin-type deacetylase, SIRT1, which deacetylates histones and p53.^[6]^[7] DBC1 is likely to regulate the activity of SIRT1 or related deacetylases by sensing the soluble products or substrates of the NAD-dependent deacetylation reaction.^[8]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: KIAA1967 KIAA1967".
↑ Nagase T, Kikuno R, Ohara O (December 2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. PMID 11853319. doi:10.1093/dnares/8.6.319.
↑ Hamaguchi M, Meth JL, von Klitzing C, Wei W, Esposito D, Rodgers L, Walsh T, Welcsh P, King MC, Wigler MH (October 2002). "DBC2, a candidate for a tumor suppressor gene involved in breast cancer". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13647–52. PMC 129730 . PMID 12370419. doi:10.1073/pnas.212516099.
↑ Kim JE, Chen J, Lou Z (January 2008). "DBC1 is a negative regulator of SIRT1". Nature. 451 (7178): 583–6. PMID 18235501. doi:10.1038/nature06500.
↑ Zhao W, Kruse JP, Tang Y, Jung SY, Qin J, Gu W (January 2008). "Negative regulation of the deacetylase SIRT1 by DBC1". Nature. 451 (7178): 587–90. PMC 2866287 . PMID 18235502. doi:10.1038/nature06515.
↑ Anantharaman V, Aravind L (May 2008). "Analysis of DBC1 and its homologs suggests a potential mechanism for regulation of Sirtuin domain deacetylases by NAD metabolites". Cell Cycle. 7 (10): 1467–72. PMC 2423810 . PMID 18418069. doi:10.4161/cc.7.10.5883.

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. PMC 310948 . PMID 11076863. doi:10.1101/gr.143000.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. PMC 311072 . PMID 11230166. doi:10.1101/gr.GR1547R.
Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. PMID 11853319. doi:10.1093/dnares/8.6.319.
Hamaguchi M, Meth JL, von Klitzing C, et al. (2002). "DBC2, a candidate for a tumor suppressor gene involved in breast cancer". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13647–52. PMC 129730 . PMID 12370419. doi:10.1073/pnas.212516099.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. PMID 14743216. doi:10.1038/ncb1086.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. PMC 514446 . PMID 15302935. doi:10.1073/pnas.0404720101.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics. 3 (11): 1093–101. PMID 15345747. doi:10.1074/mcp.M400085-MCP200.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. PMC 528930 . PMID 15489336. doi:10.1101/gr.2576704.
Sundararajan R, Chen G, Mukherjee C, White E (2005). "Caspase-dependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling". Oncogene. 24 (31): 4908–20. PMID 15824730. doi:10.1038/sj.onc.1208681.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. PMC 1347501 . PMID 16381901. doi:10.1093/nar/gkj139.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. PMID 17081983. doi:10.1016/j.cell.2006.09.026.
Koch HB, Zhang R, Verdoodt B, et al. (2007). "Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach". Cell Cycle. 6 (2): 205–17. PMID 17314511. doi:10.4161/cc.6.2.3742.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. PMC 1847948 . PMID 17353931. doi:10.1038/msb4100134.
Trauernicht AM, Kim SJ, Kim NH, Boyer TG (2007). "Modulation of estrogen receptor alpha protein level and survival function by DBC-1". Mol. Endocrinol. 21 (7): 1526–36. PMID 17473282. doi:10.1210/me.2007-0064.

KIAA human genes
KIAA0020 KIAA0101 KIAA0157 KIAA0174 KIAA0182 KIAA0196 KIAA0243 KIAA0274 KIAA0319 KIAA0368 KIAA0409 KIAA0430 KIAA0460 KIAA0515 KIAA0802 KIAA0859 KIAA0895 KIAA0999 KIAA1012 KIAA1109 KIAA1166 KIAA1199 KIAA1219 KIAA1267 KIAA1279 KIAA1303 KIAA1333 KIAA1377 KIAA1524 KIAA1539 KIAA1683 KIAA1826 KIAA1949 KIAA1967

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KIAA1967

Function

References

Further reading