Calsenilin

KCNIP3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKCNIP3, CSEN, DREAM, KCHIP3, potassium voltage-gated channel interacting protein 3
External IDsMGI: 1929258 HomoloGene: 8382 GeneCards: KCNIP3
Orthologs
SpeciesHumanMouse
Entrez

30818

56461

Ensembl

ENSG00000115041

ENSMUSG00000079056

UniProt

Q9Y2W7

Q9QXT8
P0C092

RefSeq (mRNA)

NM_001034914
NM_013434

NM_001111331
NM_001291005
NM_019789

RefSeq (protein)

NP_001030086
NP_038462

NP_001104801
NP_001277934
NP_062763

Location (UCSC)Chr 2: 95.3 – 95.39 MbChr 2: 127.46 – 127.52 Mb
PubMed search[1][2]
Wikidata
View/Edit HumanView/Edit Mouse

Calsenilin is a protein that in humans is encoded by the KCNIP3 gene.[3][4][5]

Function

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the neuronal calcium sensor family of proteins.[6][7] Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. In addition, the protein has been shown to transcriptionally repress A20 (TNFAIP3) expression and thus modulate the anti-inflammatory signaling.[8] Alternatively spliced transcript variants encoding different isoforms have been described.[5]

Interactions

Calsenilin has been shown to interact with PSEN1[3][9] and PSEN2.[3][10]

See also

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. 1 2 3 Buxbaum JD, Choi EK, Luo Y, Lilliehook C, Crowley AC, Merriam DE, Wasco W (October 1998). "Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment". Nat Med. 4 (10): 1177–81. PMID 9771752. doi:10.1038/2673.
  4. ↑ Carrión AM, Link WA, Ledo F, Mellström B, Naranjo JR (March 1999). "DREAM is a Ca2+-regulated transcriptional repressor". Nature. 398 (6722): 80–4. PMID 10078534. doi:10.1038/18044.
  5. 1 2 "Entrez Gene: KCNIP3 Kv channel interacting protein 3, calsenilin".
  6. ↑ Burgoyne RD (2007). "Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling". Nat. Rev. Neurosci. 8 (3): 182–193. PMC 1887812 Freely accessible. PMID 17311005. doi:10.1038/nrn2093.
  7. ↑ Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV (2004). "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends Neurosci. 27 (4): 203–9. PMID 15046879. doi:10.1016/j.tins.2004.01.010.
  8. ↑ Tiruppathi C, Soni D, Wang DM, et al. (March 2014). "The transcription factor DREAM represses A20 and mediates inflammation". Nat Immunol. 15 (3): 239–247. PMC 4005385 Freely accessible. PMID 4005385. doi:10.1038/ni.2823.
  9. ↑ Kashiwa A, Yoshida H, Lee S, Paladino T, Liu Y, Chen Q, Dargusch R, Schubert D, Kimura H (July 2000). "Isolation and characterization of novel presenilin binding protein". J. Neurochem. 75 (1): 109–16. PMID 10854253. doi:10.1046/j.1471-4159.2000.0750109.x.
  10. ↑ Choi EK, Zaidi NF, Miller JS, Crowley AC, Merriam DE, Lilliehook C, Buxbaum JD, Wasco W (June 2001). "Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2". J. Biol. Chem. 276 (22): 19197–204. PMID 11278424. doi:10.1074/jbc.M008597200.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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