Julie Ahringer

Julie Ahringer
Born Julie Ann Ahringer
Fields

Developmental Biology Genomics

Genetics
Institutions Gurdon Institute
University of Cambridge
Laboratory of Molecular Biology
University of Wisconsin–Madison
Alma mater
Thesis Post-transcriptional regulation of fem-3, a sex-determining gene of Caenorhabditis elegans (1991)
Doctoral advisor Judith Kimble
Other academic advisors John Graham White
Known for RNA interference[1]
Caenorhabditis elegans[2][3][4][5][6]
Notable awards
Spouse Richard Durbin (m. 1996)[7]
Website
www.ahringer.group.gurdon.cam.ac.uk

Julie Ann Ahringer FMedSci is a Professor of Genetics and Genomics, and a Wellcome Trust Senior Research Fellow at the Gurdon Institute and the Department of Genetics at the University of Cambridge.[8][9][10][11][12] She leads a research lab investigating the control of gene expression.[8]

Education

Ahringer was educated at Lafayette College in Easton, Pennsylvania where she was awarded a Bachelor of Arts degree in Chemistry in 1984.[13] She completed her PhD at the University of Wisconsin–Madison while working with Judith Kimble.[14][15][16] She carried out postdoctoral research at the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) in Cambridge with John Graham White.[17]

Research

Ahringer became a group leader in the Department of Genetics in Cambridge in 1996, then moved to the Gurdon Institute in 1998. Her laboratory carried out the first systematic inactivation of the majority of genes in any animal by constructing and screening a genome-wide RNAi library for Caenorhabditis elegans (C. elegans). Ahringer's current research group studies the regulation of chromatin structure and function in gene expression and genome organization using the nematode C. elegans as a model to understand development and disease. The Ahringer Lab research is funded by the Wellcome Trust.[8]

Honours and awards

Ahringer was elected to the EMBO Membership in 2003 and a Fellow of the Academy of Medical Sciences in 2007. She delivered the Francis Crick lecture prize of the Royal Society in 2004.[18] She is the member of the Scientific Advisory Board of the Medical Research Council (MRC) along with many other eminent scientists.[19]

Personal life

Ahringer married Richard Durbin in 1996, with whom she has two children.[7]

References

  1. ↑ Qu, W.; Ren, C.; Li, Y.; Shi, J.; Zhang, J.; Wang, X.; Hang, X.; Lu, Y.; Zhao, D.; Zhang, C. (2011). "Reliability analysis of the Ahringer Caenorhabditis elegans RNAi feeding library: A guide for genome-wide screens". BMC Genomics. 12: 170. PMC 3087708 Freely accessible. PMID 21453524. doi:10.1186/1471-2164-12-170.
  2. ↑ Kamath, R.; Fraser, A.; Dong, Y.; Poulin, G.; Durbin, R.; Gotta, M.; Kanapin, A.; Le Bot, N.; Moreno, S.; Sohrmann, M.; Welchman, D. P.; Zipperlen, P.; Ahringer, J. (2003). "Systematic functional analysis of the Caenorhabditis elegans genome using RNAi". Nature. 421 (6920): 231–237. PMID 12529635. doi:10.1038/nature01278.
  3. ↑ Ahringer, J.; Kamath, A. G.; Zipperlen, R. S.; Martinez-Campos, P.; Sohrmann, M.; Ahringer, M. (2000). "Functional genomic analysis of C. Elegans chromosome I by systematic RNA interference". Nature. 408 (6810): 325–330. PMID 11099033. doi:10.1038/35042517.
  4. ↑ Murphy, C. T.; McCarroll, S. A.; Bargmann, C. I.; Fraser, A.; Kamath, R. S.; Ahringer, J.; Li, H.; Kenyon, C. (2003). "Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans". Nature. 424 (6946): 277–283. PMID 12845331. doi:10.1038/nature01789.
  5. ↑ Ashrafi, K.; Chang, F. Y.; Watts, J. L.; Fraser, A. G.; Kamath, R. S.; Ahringer, J.; Ruvkun, G. (2003). "Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes". Nature. 421 (6920): 268–272. PMID 12529643. doi:10.1038/nature01279.
  6. ↑ Lee, S. S.; Lee, R. Y. N.; Fraser, A. G.; Kamath, R. S.; Ahringer, J.; Ruvkun, G. (2002). "A systematic RNAi screen identifies a critical role for mitochondria in C. Elegans longevity". Nature Genetics. 33 (1): 40–48. PMID 12447374. doi:10.1038/ng1056.
  7. 1 2 DURBIN, Richard Michael. ukwhoswho.com. Who's Who. 2006 (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. (subscription required)
  8. 1 2 3 Florence Leroy based on Custom Repute template. "Home | Ahringer Lab". Gurdon.cam.ac.uk. Archived from the original on 2016-10-17. Retrieved 2016-12-19.
  9. ↑ Julie Ahringer's publications indexed by the Scopus bibliographic database, a service provided by Elsevier. (subscription required)
  10. ↑ Julie Ahringer's publications indexed by Google Scholar
  11. ↑ List of publications from Microsoft Academic Search
  12. ↑ Pocock, R.; Ahringer, J.; Mitsch, M.; Maxwell, S.; Woollard, A. (2004). "A regulatory network of T-box genes and the even-skipped homologue vab-7 controls patterning and morphogenesis in C. Elegans". Development. 131 (10): 2373–2385. PMID 15102704. doi:10.1242/dev.01110.
  13. ↑ Julie Ahringer Entry at ORCID
  14. ↑ Ahringer, Julie Ann (1991). Posttranscriptional regulation offem-3, a sex-determining gene of Caenorhabditis elegans (PhD thesis). University of Wisconsin–Madison.
  15. ↑ Ahringer, J.; Rosenquist, T. A.; Lawson, D. N.; Kimble, J. (1992). "The Caenorhabditis elegans sex determining gene fem-3 is regulated post-transcriptionally". The EMBO Journal. 11 (6): 2303–2310. PMC 556697 Freely accessible. PMID 1376249.
  16. ↑ Ahringer, J.; Kimble, J. (1991). "Control of the sperm–oocyte switch in Caenorhabditis elegans hermaphrodites by the fem-3 3′ untranslated region". Nature. 349 (6307): 346–348. PMID 1702880. doi:10.1038/349346a0.
  17. ↑ Malone, C. J.; Misner, L.; Le Bot, N.; Tsai, M. C.; Campbell, J. M.; Ahringer, J.; White, J. G. (2003). "The C. Elegans hook protein, ZYG-12, mediates the essential attachment between the centrosome and nucleus". Cell. 115 (7): 825–836. PMID 14697201. doi:10.1016/S0092-8674(03)00985-1.
  18. ↑ Ahringer, Julie (2004). "Genes, worms and the new genetics". royalsociety.org. London: Royal Society.
  19. ↑ "Scientific Advisory Board". Csc.mrc.ac.uk. Archived from the original on 2012-07-03. Retrieved 2016-12-19.
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