Joachim Frank

Joachim Frank (born September 12, 1940 in Weidenau/Sieg) is a German-born biophysicist at Columbia University, New York City. He is regarded as the founder of single-particle cryo-electron microscopy (cryo-EM) and made significant contributions to structure and function of the ribosome from bacteria and eukaryotes.

Career

After completing his Vordiplom (B.S.) degree in Physics at the University of Freiburg (1963) ^[1] and his Diplom (M.S.) under Walter Rollwagen’s mentorship at the Ludwig Maximilians University of Munich with the thesis “Untersuchung der Sekundärelektronen-Emission von Gold am Schmelzpunkt” (Investigation of secondary electron emission of gold at its melting point) (1967), Frank obtained his Ph.D. from the Technical University of Munich for graduate studies in Walter Hoppe’s lab at the Max Planck Institut für Eiweiss- und Lederforschung (now Max Planck Institut fűr Biochemie) with the dissertation Untersuchungen von elektronenmikroskopischen Aufnahmen hoher Auflösung mit Bilddifferenz- und Rekonstruktionsverfahren^[2] (Investigations of high-resolution electron micrographs using image difference and reconstruction methods) (1970). The thesis explores the use of digital image processing and optical diffraction in the analysis of electron micrographs, and alignment of images using the cross-correlation function.

As a Harkness postdoctoral fellow he had the opportunity to study for two years in the United States: with Robert Nathan at the Jet Propulsion Laboratory, California Institute of Technology; with Robert M. Glaeser at Donner Lab, University of California, Berkeley and with Benjamin M. Siegel at Cornell University, Ithaca, New York.^[3] In the fall of 1972 he returned briefly to the Max Planck Institute of Biochemistry in Martinsried as research assistant, working on the theory of partial coherence in electron microscopy ^[4], then, in 1973, he joined the Cavendish Laboratory, University of Cambridge as Senior Research Assistant under Vernon Ellis Cosslett.

In 1975 Frank was offered a position of Senior Research Scientist in the Division of Laboratories and Research (now Wadsworth Center), New York State Department of Health ^[5]; Wicher, Konrad (2006). History of the electron microscope: the high voltage electron microscope and beyond at the Division of Laboratories and Research/Wadsworth Center. Albany, New York: Wadsworth Center, New York State Department of Health. p. 149.  , where he started working on single-particle approaches in electron microscopy.^[6] In 1985 he was appointed Associate and then (1986) Full Professor at the newly formed Department of Biomedical Sciences of the University at Albany, State University of New York. In 1987 and 1994, he went on Sabbaticals in Europe, one to work with Richard Henderson, Laboratory of Molecular Biology Medical Research Council in Cambridge and the other with Kenneth C. Holmes, Max Planck Institute for Medical Research in Heidelberg.^[7] In 1998 Frank was appointed Investigator of the Howard Hughes Medical Institute (HHMI). Since 2003 he was also lecturer at Columbia University, and he joined Columbia University in 2008 as Professor of Biochemistry and Molecular Biophysics and of Biological Sciences.

Awards (selection)

• 2006 Fellow of the American Academy of Arts and Sciences^[8]
• 2006 Member of the National Academy of Sciences^[9]
• 2014 Benjamin Franklin Medal in Life Science of the Franklin Institute^[10]
• 2017 Wiley Prize in Biomedical Sciences^[11]

Literature

Mossman, K. (December 11, 2007). "Profile of Joachim Frank". Proceedings of the National Academy of Sciences of the USA. 104: 19668. doi:10.1073/pnas.0710323105. 

Selected publications

Books

• Frank, Joachim (2014), Found in Translation – Collection of Original Articles on Single-Particle Reconstruction and the Structural Basis of Protein Synthesis, Singapore: World Scientific Press, ISBN 978-9814522809 .
• Frank, Joachim (2011), Molecular Machines in Biology: Workshop of the Cell, Cambridge: Cambridge University Press, ISBN 978-0-521-19428-0 .
• Glaeser, Robert M.; Downing, Ken; Chiu, Wah; Frank, Joachim; DeRosier, David (2007), Electron Crystallography of Biological Macromolecules, Oxford: Oxford University Press, ISBN 978-0-19-508871-7 .
• Frank, Joachim (2006), Electron Tomography (2nd ed.), New York: Springer, ISBN 978-0387312347 .
• Frank, Joachim (2006), Three-Dimensional Electron Microscopy of Macromolecular Assemblies (2nd ed.), Oxford: Oxford University Press, ISBN 978-0195182187 .

Articles

• Frank, Joachim (2015). "Generalized single-particle cryo-EM – a historical perspective". Microscopy. 65: 3–8. PMID 26566976. doi:10.1093/jmicro/dfv358. 
• Frank, Joachim; Gonzales, Ruben L. (2010). "Structure and dynamics of a processive Brownian motor: the translating ribosome". Ann. Rev. Biochem. 79: 381–412. PMID 20235828. doi:10.1146/annurev-biochem-060408-173330. 
• Frank, Joachim; Spahn, , Christian M.T (2010). "The ribosome and the mechanism of protein synthesis". Rep. Progr. Phys. 69: 1383–1417. doi:10.1088/0034-4885/69/5/R03. 
• Frank, Joachim (2009). "Single-particle reconstruction of biological macromolecules in electron microscopy -- 30 years". Q. Rev. Biophys. 42: 139–158. PMID 20025794. doi:10.1017/S0033583509990059. 

References

External links

• Frank Lab website
• List of Publications