Isopropamide

Isopropamide
Clinical data

MedlinePlus	a694006
Routes of administration	Oral
ATC code	A03AB09 (WHO)
Legal status
Legal status	US: ℞-only and Unscheduled In general: unscheduled
Identifiers
IUPAC name 4-amino-N,N-diisopropyl-N-methyl-4-oxo-3,3-diphenylbutan-1-aminium
CAS Number	7492-32-2^N
PubChem CID	3775
DrugBank	DB01625^Y
ChemSpider	3643^Y
UNII	8B9I31H724
ChEMBL	CHEMBL1201232^N
ECHA InfoCard	100.028.470
Chemical and physical data
Formula	C₂₃H₃₃N₂O⁺
Molar mass	353.52092 g/mol
3D model (JSmol)	Interactive image
SMILES O=C(N)C(c1ccccc1)(c2ccccc2)CC[N+](C(C)C)(C(C)C)C
InChI InChI=1S/C23H32N2O/c1-18(2)25(5,19(3)4)17-16-23(22(24)26,20-12-8-6-9-13-20)21-14-10-7-11-15-21/h6-15,18-19H,16-17H2,1-5H3,(H-,24,26)/p+1^Y Key:JTPUMZTWMWIVPA-UHFFFAOYSA-O^Y
^NY (what is this?) (verify)

Isopropamide (R5) is a long-acting anticholinergic drug. It is used in the treatment of peptic ulcers and other gastrointestinal disorders involving hyperacidity (gastrointestinal acidosis) and hypermotility. Chemically, it contains a quaternary ammonium group. It is most often provided as an iodide salt, but is also available as a bromide or chloride salt. It was discovered at Janssen Pharmaceutica in 1954.

References

Seeherman R, Isopropamide iodide: a long-acting anticholinergic, Del Med J. 1957 Oct;29(10):265-9.
Boss EG Jr, Buchanan GC, Effect of isopropamide iodide on basal gastric secretion in the human, Gastroenterology. 1957 Nov;33(5):730-6.

Tertiary amino group	Oxyphencyclimine Camylofin Mebeverine Trimebutine Rociverine Dicycloverine Dihexyverine Difemerine Piperidolate
Quaternary ammonium compounds	Benzilone Mepenzolate Pipenzolate Glycopyrronium Oxyphenonium Penthienate Methantheline Propantheline Otilonium Tridihexethyl Isopropamide Hexocyclium Poldine Bevonium Diphemanil Tiemonium Prifinium Timepidium Fenpiverinium

Other

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