Insulin-like growth factor II IRES

Insulin-like growth factor II IRES

Predicted secondary structure and sequence conservation of IRES_IGF2
Identifiers
Symbol IRES_IGF2
Rfam RF00483
Other data
RNA type Cis-reg; IRES
Domain(s) Eukaryota
GO 0043022
SO 0000243

The insulin-like growth factor II (IGF-II) internal ribosome entry site IRES is found in the 5' UTR of IGF-II leader 2 mRNA. This RNA element allows cap-independent translation of the mRNA and it is thought that this family may facilitate a continuous IGF-II production in rapidly dividing cells during development.[1] Ribosomal scanning on human insulin-like growth factor II (IGF-II) is hard to comprehend due to one open reading frame and the ability for the hormone to fold into a stable structure. [2]

References

  1. ↑ Pedersen, SK; Christiansen J; Hansen TO; Larsen MR; Nielsen FC (2002). "Human insulin-like growth factor II leader 2 mediates internal initiation of translation". Biochem J. 363 (Pt 1): 37–44. PMC 1222448 Freely accessible. PMID 11903044. doi:10.1042/0264-6021:3630037.
  2. ↑ van der Velden, Alike W.; van Nierop, Kirsten; Voorma, Harry O.; Thomas, Adri A. M. (2002-03-01). "Ribosomal scanning on the highly structured insulin-like growth factor II-leader 1". The International Journal of Biochemistry & Cell Biology. 34 (3): 286–297. doi:10.1016/S1357-2725(01)00116-9.
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