Insect cell culture

The use of insect cell lines as production hosts is an emerging technology for the production of bio pharmaceuticals. There are currently more than 100 insect cell lines available for recombinant protein production with lines derived from Bombyx mori, Mamestra brassicae, Spodoptera frugiperda, Trichoplusia ni, and Drosophila melanogaster being of particular interest. Insects cell lines are used because post translational modifications of protein are possible in insect cells whereas this mechanism is not present in prokaryotic system[1] The Sf9 is one of the most commonly used cell lines in insect cell culture.[2]

References and notes

  1. ↑ Drugmand, Jean-Christophe; Schneider, Yves-Jacques; Agathos, Spiros N (2011). "Insect Cells as Factories for Biomanufacturing". Biotechnology Advances. 30 (5): 1140–57. PMID 21983546. doi:10.1016/j.biotechadv.2011.09.014.
  2. ↑ Drugmand, JC; Schneider, YJ; Agathos, SN (2012). "Insect cells as factories for biomanufacturing.". Biotechnology advances. 30 (5): 1140–57. PMID 21983546. doi:10.1016/j.biotechadv.2011.09.014.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.